Universal Biomaterial-on-Chip: a versatile platform for evaluating cellular responses on diverse biomaterial substrates

Atif, Abdul Raouf,1996-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för materialvetenskap,Avdelningen för medicinsk teknik (författare)

Universal Biomaterial-on-Chip : a versatile platform for evaluating cellular responses on diverse biomaterial substrates

Microfluidics has emerged as a promising approach for assessing cellular behavior in vitro, providing more physiologically relevant cell culture environments with dynamic flow and shear stresses. This study introduces the Universal Biomaterial-on-Chip (UBoC) device, which enables the evaluation of cell response on diverse biomaterial substrates in a 3D-printed microfluidic device. The UBoC platform offers mechanical stimulation of the cells and monitoring of their response on diverse biomaterials, enabling qualitative and quantitative in vitro analysis both on- and off-chip. Cell adhesion and proliferation were assessed to evaluate the biocompatibility of materials with different physical properties, while mechanical stimulation was performed to investigate shear-dependent calcium signaling in pre-osteoblasts. Moreover, the applicability of the UBoC platform in creating more complex in vitro models by culturing multiple cell types was demonstrated, establishing a dynamic multicellular environment to investigate cellular interfaces and their significance in biological processes. Overall, the UBoC presents an adaptable tool for in vitro evaluation of cellular behavior, offering opportunities for studying various biomaterials and cell interactions in microfluidic environments.

Aramesh, MortezaUppsala universitet,Institutionen för materialvetenskap,Science for Life Laboratory, SciLifeLab,Avdelningen för medicinsk teknik(Swepub:uu)morar401 (författare)
Carter, Sarah-Sophia,1994-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för materialvetenskap,Avdelningen för medicinsk teknik(Swepub:uu)sarca385 (författare)
Tenje, MariaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för materialvetenskap,Avdelningen för medicinsk teknik(Swepub:uu)marte323 (författare)
Mestres, Gemma,1984-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för materialvetenskap,Avdelningen för medicinsk teknik(Swepub:uu)gemme924 (författare)
Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Ingår i:Journal of materials science. Materials in medicine: Springer350957-45301573-4838

Av författaren/redakt...: Atif, Abdul Raou ...; Aramesh, Morteza; Carter, Sarah-So ...; Tenje, Maria; Mestres, Gemma, ...

Om ämnet

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk materi ...

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