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Morbidity and Morta...
Morbidity and Mortality Associated With Heart Failure in Acute Coronary Syndrome : A Pooled Analysis of 4 Clinical Trials
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- Goodwin, Nathan P. (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
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- Clare, Robert M. (author)
- Duke Univ, Sch Med, Durham, NC USA.
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- Harrington, Josephine L. (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
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- Badjatiya, Anish (author)
- Texas Heart Inst, Baylor Coll Med, Dept Med, Div Cardiol, Houston, TX USA.
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- Wojdyla, Daniel M. (author)
- Duke Univ, Sch Med, Durham, NC USA.
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- Udell, Jacob A. (author)
- Womens Coll Hosp, Dept Med, Cardiovasc Div, Toronto, ON, Canada.;Univ Toronto, Toronto Gen Hosp, Peter Munk Cardiac Ctr, Toronto, ON, Canada.
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- Butler, Javed (author)
- Univ Mississippi, Dept Med, Jackson, MS USA.
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- Januzzi Jr, James L. (author)
- Massachusetts Gen Hosp & Cardiac Trials, Baim Inst Clin Res, Div Cardiol, Boston, MA USA.
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- Parikh, Puja B. (author)
- SUNY Stony Brook, Med Ctr, Div Cardiovasc Med, Stony Brook, NY USA.
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- James, Stefan, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Alexander, John H. (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.;Duke Univ, Sch Med, Durham, NC USA.
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- Lopes, Renato D. (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Ohman, E. Magnus (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
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- Hernandez, Adrian F. (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
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- Jones, W. Schuyler (author)
- Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA.
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Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC USA Duke Univ, Sch Med, Durham, NC USA. (creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: Journal of Cardiac Failure. - : Elsevier. - 1071-9164 .- 1532-8414. ; 29:12, s. 1603-1614
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Heart failure (HF) may complicate acute coronary syndrome (ACS) and is associ-ated with a high burden of short-and long-term morbidity and mortality. Only limited data regarding future ischemic events and rehospitalization are available for patients who suffer HF before or during ACS.Methods: A secondary analysis of 4 large ACS trials (PLATO, APPRAISE-2, TRACER, and TRIL-OGY ACS) using Cox proportional hazards models was performed to investigate the associa-tion of HF status (no HF, chronic HF, de novo HF) at presentation for ACS with all-cause and cardiovascular death, major adverse cardiovascular event (MACE ), myocardial infarction, stroke, and hospitalization for heart failure (HHF) by 1 year. Cumulative incidence plots are presented at 30 days and 1 year.Results: A total of 11.1% of the 47,474 patients presenting with ACS presented with evidence of acute HF, 55.0% of whom presented with de novo HF. Patients with chronic HF presented with evidence of acute HF at a higher rate than those with no previous HF (40.3% vs 6.9%). Compared to those without HF, those with chronic and de novo HF had higher rates of all-cause mortality (adjusted hazard ratio [aHR] 2.01, 95% confidence interval [CI] 1.72-2.34 and aHR 1.47, 95% CI1.15-1.88, respectively), MACE (aHR 1.47, 95% CI1.31-1-.66 and aHR 1.38, 95% CI1.12-1.69), and HHF (aHR 2.29, 95% CI2.02-2.61 and aHR 1.48, 95% CI 1.20-1.82) at 1 year.Conclusion: In this large cohort of patients with ACS, both prior and de novo HF complicating ACS were associated with significantly higher risk-adjusted rates of death, ischemic events and HHF at 30 days and 1 year. Further studies examining the association between HF and out-comes in this high-risk population are warranted, especially given the advent of more contem-porary HF therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Acute coronary syndrome
- heart failure
- ischemic events
- hospitalization
Publication and Content Type
- ref (subject category)
- art (subject category)
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Goodwin, Nathan ...
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Clare, Robert M.
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Harrington, Jose ...
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Badjatiya, Anish
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Wojdyla, Daniel ...
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Udell, Jacob A.
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Butler, Javed
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Januzzi Jr, Jame ...
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Parikh, Puja B.
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James, Stefan, 1 ...
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Alexander, John ...
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Lopes, Renato D.
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Wallentin, Lars, ...
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Ohman, E. Magnus
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Hernandez, Adria ...
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Jones, W. Schuyl ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Journal of Cardi ...
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Uppsala University