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  • Brito-Zeron, P.Sanitas Digital Hosp, Hosp CIMA Ctr Med Milenium Balmes Sanitas, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Barcelona, Spain. (author)

Exposure to air pollution as an environmental determinant of how Sjögren's disease is expressed at diagnosis

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Clinical and Experimental Rheumatology,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-521892
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-521892URI
  • https://doi.org/10.55563/clinexprheumatol/p1r1j4DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • ObjectiveTo analyse how the potential exposure to air pollutants can influence the key components at the time of diagnosis of Sjogren's phenotype (epidemiological profile, sicca symptoms, and systemic disease). MethodsFor the present study, the following variables were selected for harmonisation and refinement: age, sex, country, fulfilment of 2002/2016 criteria items, dry eyes, dry mouth, and overall ESSDAI score. Air pollution indexes per country were defined according to the OECD (1990-2021), including emission data of nitrogen and sulphur oxides (NO/SO), particulate matter (PM2.5 and 1.0), carbon monoxide (CO) and volatile organic compounds (VOC) calculated per unit of GDP, Kg per 1000 USD.ResultsThe results of the chi-square tests of independence for each air pollutant with the frequency of dry eyes at diagnosis showed that, except for one, all variables exhibited p-values <0.0001. The most pronounced disparities emerged in the dry eye prevalence among individuals inhabiting countries with the highest NO/SO exposure, a surge of 4.61 percentage points compared to other countries, followed by CO (3.59 points), non-methane (3.32 points), PM2.5 (3.30 points), and PM1.0 (1.60 points) exposures. Concerning dry mouth, individuals residing in countries with worse NO/SO exposures exhibited a heightened frequency of dry mouth by 2.05 percentage points (p<0.0001), followed by non-methane exposure (1.21 percentage points increase, p=0.007). Individuals inhabiting countries with the worst NO/SO, CO, and PM2.5 pollution levels had a higher mean global ESSDAI score than those in lower-risk nations (all p-values <0.0001). When systemic disease was stratified according to DAS into low, moderate, and high systemic activity levels, a heightened proportion of individuals manifesting moderate/severe systemic activity was observed in countries with worse exposures to NO/SO, CO, and PM2.5 pollutant levels. ConclusionFor the first time, we suggest that pollution levels could influence how SjD appears at diagnosis in a large international cohort of patients. The most notable relationships were found between symptoms (dryness and general body symptoms) and NO/SO, CO, and PM2.5 levels.

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  • Flores-Chavez, A.Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain. (author)
  • Ng, W. -F (author)
  • Horvath, I. FannyUniv Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary. (author)
  • Rasmussen, A.Oklahoma Med Res Fdn, Genes & Human Dis Res Program, Oklahoma City, OK USA. (author)
  • Priori, R.Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy.;St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy. (author)
  • Baldini, C.Univ Pisa, Rheumatol Unit, Pisa, Italy. (author)
  • Armagan, B.Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye. (author)
  • Ozkiziltas, B.Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye. (author)
  • Praprotnik, S.Univ Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia. (author)
  • Suzuki, Y.Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan. (author)
  • Quartuccio, L.Univ Udine, Univ Hosp Santa Maria della Misericordia, Dept Med, Div Rheumatol, Udine, Italy. (author)
  • Hernandez-Molina, G.Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico. (author)
  • Abacar, K.Marmara Univ, Sch Med, Istanbul, Turkiye. (author)
  • Bartoloni, E.Univ Perugia, Dept Med, Rheumatol Unit, Perugia, Italy. (author)
  • Rischmueller, M.Univ Adelaide, Queen Elizabeth Hosp, Discipline Med, Dept Rheumatol, Adelaide, SA, Australia. (author)
  • Reis-de Oliveira, F.Univ Sao Paulo, Ribeirao Preto Med Sch, Clin Hosp, Ribeirao Preto, Brazil. (author)
  • Trevisani, V. Fernandes MocaUniv Fed Sao Paulo, Div Hlth Based Evidence, Sao Paulo, Brazil. (author)
  • Jurcut, C.Carol Davila Cent Mil Emergency Hosp, Dept Internal Med, Bucharest, Romania. (author)
  • Fugmann, CeciliaUppsala universitet,Reumatologi(Swepub:uu)cecfu607 (author)
  • Carubbi, F.San Salvatore Hosp, Internal Med & Nephrol Unit, ASL Avezzano Sulmona LAquila, Dept Med, Laquila, Italy. (author)
  • Hofauer, B.Med Univ Innsbruck, Otorhinolaryngol Head & Neck Surg, Innsbruck, Austria. (author)
  • Valim, V.Univ Fed Espirito Santo, Vitoria, Spain. (author)
  • Pasoto, S. G.Univ Sao Paulo, Fac Med, Rheumatol Div, Hosp Clin HCFMUSP, Jundiai, Brazil. (author)
  • Retamozo, S.Hosp Quiron Salud, Dept Rheumatol, Barcelona, Spain. (author)
  • Atzeni, F.IRCCS Galeazzi Orthopaed Inst, Milan, Italy.;Univ Messina, Rheumatol Unit, Messina, Italy. (author)
  • Fonseca-Aizpuru, E.Hosp Cabuenes, Dept Internal Med, Gijon, Spain. (author)
  • Lopez-Dupla, M.Hosp Joan 23, Dept Internal Med, Tarragona, Spain. (author)
  • Giacomelli, R.Univ Rome Campus Biomed, Clin Unit Rheumatol & Clin Immunol, Rome, Italy. (author)
  • Nakamura, H.Nihon Univ, Dept Med, Div Haematol & Rheumatol, Sch Med, Oyaguchi Kami Cho,Itabashi Ku, Tokyo, Japan. (author)
  • Akasbi, M.Hosp Infanta Leonor, Dept Internal Med, Madrid, Spain. (author)
  • Thompson, K.United Kingdom Primary Sjogrens Syndrome Registry, Newcastle NIHR Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England. (author)
  • Szanto, A.Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary. (author)
  • Farris, A. D.Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, Oklahoma City, OK USA. (author)
  • Villa, M.Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rheumatol Clin, Rome, Italy.;St Camillus Int Univ Hlth Sci, UniCamillus, Rome, Italy. (author)
  • Bombardieri, S.Univ Pisa, Rheumatol Unit, Pisa, Italy. (author)
  • Kilic, L.Hacettepe Univ, Fac Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye. (author)
  • Tufan, A.Gazi Univ, Sch Med, Dept Internal Med, Div Rheumatol, Ankara, Turkiye. (author)
  • Pirkmajer, K. PerdanUniv Med Ctr Ljubljana, Dept Rheumatol, Llubljana, Slovenia.;Univ Ljubljana, Fac Med, Dept Internal Med, Ljubljana, Slovenia. (author)
  • Fujisawa, Y.Kanazawa Univ Hosp, Div Rheumatol, Kanazawa, Ishikawa, Japan. (author)
  • De Vita, S.Univ Udine, Univ Hosp Santa Maria della Misericordia, Dept Med, Div Rheumatol, Udine, Italy. (author)
  • Inanc, N.Marmara Univ, Sch Med, Istanbul, Turkiye. (author)
  • Ramos-Casals, M.Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain.;Univ Barcelona, Dept Med, Barcelona, Spain. (author)
  • Sanitas Digital Hosp, Hosp CIMA Ctr Med Milenium Balmes Sanitas, Autoimmune Dis Unit, Res & Innovat Grp Autoimmune Dis, Barcelona, Spain.Hosp Clin Barcelona, Dept Autoimmune Dis, ICMiD, Barcelona, Spain. (creator_code:org_t)

Related titles

  • In:Clinical and Experimental Rheumatology: Clinical and Experimental Rheumatology41:12, s. 2448-24570392-856X1593-098X

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