WFRF:(Godina Christopher)
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Caveolin-1 genotypes as predictor for locoregional recurrence and contralateral disease in breast cancer
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- Godina, Christopher (författare)
- Lund University,Lunds universitet,Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, S-22185 Lund, Sweden.;Skane Univ Hosp, Barngatan 4, S-22185 Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Tryggvadottir, Helga (författare)
- Lund University,Lunds universitet,Epidemiologi och farmakogenetik,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Epidemiology and pharmacogenetics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Bosch, Ana (författare)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylära behandlingsstrategier vid bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular therapeutics in breast cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Lund Univ, Dept Clin Sci Lund, Div Oncol, Barngatan 4, S-22185 Lund, Sweden;Skane Univ Hosp, Barngatan 4, S-22185 Lund, Sweden. LUCC: Lunds universitets cancercentrum (creator_code:org_t)
- Springer, 2023
- 2023
- Engelska.
- Ingår i: Breast Cancer Research and Treatment. - : Springer. - 0167-6806 .- 1573-7217. ; 199:2, s. 335-347
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- PurposeCaveolin-1 (CAV1) has been implicated in breast cancer oncogenesis and metastasis and may be a potential prognosticator, especially for non-distant events. CAV1 functions as a master regulator of membrane transport and cell signaling. Several CAV1 SNPs have been linked to multiple cancers, but the prognostic impact of CAV1 SNPs in breast cancer remains unclear. Here, we investigated CAV1 polymorphisms in relation to clinical outcomes in breast cancer.MethodsA cohort of 1017 breast cancer patients (inclusion 2002–2012, Sweden) were genotyped using Oncoarray by Ilumina. Patients were followed for up to 15 years. Five out of six CAV1 SNPs (rs10256914, rs959173, rs3807989, rs3815412, and rs8713) passed quality control and were used for haplotype construction. CAV1 genotypes and haplotypes in relation to clinical outcomes were assessed with Cox regression and adjusted for potential confounders (age, tumor characteristics, and adjuvant treatments).ResultsOnly one SNP was associated with lymph node status, no other SNPs or haplotypes were associated with tumor characteristics. The CAV1 rs3815412 CC genotype (5.8% of patients) was associated with increased risk of contralateral breast cancer, adjusted hazard ratio (HRadj) 4.26 (95% CI 1.86–9.73). Moreover, the TTACA haplotype (13% of patients) conferred an increased risk for locoregional recurrence HRadj 2.24 (95% CI 1.24–4.04). No other genotypes or haplotypes were associated with clinical outcome.ConclusionCAV1 polymorphisms were associated with increased risk for locoregional recurrence and contralateral breast cancer. These findings may identify patients that could derive benefit from more tailored treatment to prevent non-distant events, if confirmed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Caveolin-1
- Genotype
- Locoregional breast cancer recurrence
- Contralateral breast cancer
- Caveolin-1
- Contralateral breast cancer
- Genotype
- Locoregional breast cancer recurrence
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Breast Cancer Research and Treatment (Sök värdpublikationen i LIBRIS)
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- Bosch, Ana
- Borgquist, Signe
- Belting, Mattias
- Isaksson, Karoli ...
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- Jernström, Helen ...
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