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Certolizumab pegol,...
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Ostergaard, MikkelRigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, DK-2600 Glostrup, Copenhagen, Denmark.;Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.,University of Copenhagen,Copenhagen University Hospital
(author)
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis : 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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BMJ PUBLISHING GROUP,2023
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-523331
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523331URI
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https://doi.org/10.1136/ard-2023-224116DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-197576URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:153448247URI
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https://lup.lub.lu.se/record/e0e1127f-df8b-441d-8741-63f6d30b07ccURI
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https://gup.ub.gu.se/publication/328658URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Academy of Finland [258536]; Finska Laekaresaellskapet; South-Eastern Health Region, Norway; HUCH Institutional grant, Finland [1159005]; Icelandic Society for Rheumatology; Regionernes Medicinpulje, Denmark [14/217]; Stockholm County Council, Sweden [20100490]; Swedish Medical Research Council [C0634901, D0342301, 2015-00891_5]; Swedish Rheumatism Association; Research Fund of University Hospital, Reykjavik, Iceland [A2015017]; UCB; BMS; [70945]
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Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naive early RA with moderate-severe disease activity were randomised 1:1:1:1 to methotrexate combined with (1) active conventional therapy: oral prednisolone (tapered quickly, discontinued at week 36) or sulfasalazine, hydroxychloroquine and intra-articular glucocorticoid injections in swollen joints; (2) certolizumab pegol; (3) abatacept or (4) tocilizumab. Coprimary endpoints were week 48 Clinical Disease Activity Index (CDAI) remission (CDAI <= 2.8) and change in radiographic van der Heijde-modified Sharp Score, estimated using logistic regression and analysis of covariance, adjusted for sex, anticitrullinated protein antibody status and country. Bonferroni's and Dunnet's procedures adjusted for multiple testing (significance level: 0.025). Results Eight hundred and twelve patients were randomised. Adjusted CDAI remission rates at week 48 were: 59.3% (abatacept), 52.3% (certolizumab), 51.9% (tocilizumab) and 39.2% (active conventional therapy). Compared with active conventional therapy, CDAI remission rates were significantly higher for abatacept (adjusted difference +20.1%, p<0.001) and certolizumab (+13.1%, p=0.021), but not for tocilizumab (+12.7%, p=0.030). Key secondary clinical outcomes were consistently better in biological groups. Radiographic progression was low, without group differences. Conclusions Compared with active conventional therapy, clinical remission rates were superior for abatacept and certolizumab pegol, but not for tocilizumab. Radiographic progression was low and similar between treatments.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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van Vollenhoven, Ronald F.Karolinska Institute,Amsterdam Univ Med Ctr, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol & Clin Immunol, Amsterdam, Netherlands.,Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.
(author)
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Rudin, Anna,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xrudan
(author)
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Hetland, Merete LundRigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.,Copenhagen University Hospital,University of Copenhagen
(author)
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Heiberg, Marte SchrumpfDiakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMEDY, Oslo, Norway.,Diakonhjemmet Hospital
(author)
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Nordstrom, Dan C.Helsinki Univ Hosp, Div Internal Med & Rheumatol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.,Helsinki University Central Hospital
(author)
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Nurmohamed, Michael T.Reade, Locat VUmc, Amsterdam, Netherlands.;Amsterdam Univ Med Ctr, Amsterdam, Netherlands.,Academic Medical Center of University of Amsterdam (AMC)
(author)
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Gudbjornsson, BjornUniv Iceland, Landspitali Univ Hosp, Reykjavik, Iceland.;Ctr Rheumatol Res, Dept Rheumatol, Reykjavik, Iceland.,Centre for Rheumatology Research,National University Hospital of Iceland
(author)
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Ornbjerg, Lykke MidtbollRigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.,Copenhagen University Hospital
(author)
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Boyesen, PernilleOslo Univ Hosp, Dept Rheumatol, Oslo, Norway.,Oslo university hospital
(author)
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Lend, KristinaKarolinska Institute,Karolinska Institutet,Academic Medical Center of University of Amsterdam (AMC),Amsterdam Univ Med Ctr, Amsterdam Rheumatol Ctr, Dept Rheumatol & Clin Immunol, Amsterdam, Netherlands.;Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.
(author)
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Horslev-Petersen, KimDanish Hosp Rheumat Dis, Dept Rheumatol, Sonderborg, Denmark.;Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.,Danish Hospital for Rheumatic Diseases (IRS),University of Southern Denmark
(author)
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Uhlig, TillDiakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMEDY, Oslo, Norway.,Diakonhjemmet Hospital
(author)
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Sokka, TuulikkiUniv Eastern Finland, Jyvaskyla Cent Hosp, Jyvaskyla, Finland.,University of Eastern Finland
(author)
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Grondal, GerdurUniv Iceland, Landspitali Univ Hosp, Reykjavik, Iceland.,National University Hospital of Iceland
(author)
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Krabbe, SimonHerlev Gentofte Univ Hosp, Dept Radiol, Herlev, Denmark.
(author)
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Lindqvist, JoakimKarolinska Institute,Karolinska University Hospital,Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.
(author)
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Gjertsson, Inger,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xgjein
(author)
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Glinatsi, DanielRigshospitalet, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Denmark.;Skaraborg Hosp, Dept Rheumatol, Skovde, Sweden.,Skaraborg Hospital,Copenhagen University Hospital
(author)
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Kapetanovic, Meliha CrnkicLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ, Dept Clin Sci, Lund, Sweden.(Swepub:lu)reum-mcr
(author)
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Aga, Anna-BirgitteDiakonhjemmet Hosp, Dept Rheumatol, Oslo, Norway.,Diakonhjemmet Hospital
(author)
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Faustini, FrancescaKarolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.
(author)
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Parmanne, PinjaHelsinki Univ Hosp, Div Internal Med & Rheumatol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.,Helsinki University Central Hospital
(author)
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Lorenzen, ToveSilkeborg Univ Hosp, Dept Rheumatol, Silkeborg, Denmark.,Silkeborg Regional Hospital
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Giovanni, CagnottoLund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci, Lund, Sweden.;Skane Univ Hosp, Dept Rheumatol, Lund, Sweden.(Swepub:lu)gi7142ca
(author)
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Back, JohanUppsala Univ Hosp, Dept Med Sci, Uppsala, Sweden.,Uppsala University Hospital
(author)
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Hendricks, OliverDanish Hosp Rheumat Dis, Dept Rheumatol, Sonderborg, Denmark.;Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.,University of Southern Denmark,Danish Hospital for Rheumatic Diseases (IRS)
(author)
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Vedder, DaisyReade, Dept Rheumatol, Amsterdam, Netherlands.
(author)
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Rannio, TuomasUniv Eastern Finland, Jyvaskyla Cent Hosp, Jyvaskyla, Finland.,University of Eastern Finland
(author)
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Grenholm, EmmaDept Rheumatol, Falun, Sweden.,Mälar Hospital
(author)
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Ljosa, Maud KristineAlesund Hosp, Dept Rheumatol, Alesund, Norway.
(author)
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Brodin, EliHaukeland Hosp, Dept Rheumatol, Bergen, Norway.,Haukeland University Hospital
(author)
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Lindegaard, HanneOdense Univ Hosp, Rheumatol Res Unit, Odense, Denmark.,Odense University Hospital
(author)
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Soderbergh, AnnikaOrebro Univ Hosp, Dept Rheumatol, Orebro, Sweden.,Örebro University Hospital
(author)
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Rizk, MiladVastmanlands Hosp Vasteras, Dept Rheumatol, Vasteras, Sweden.
(author)
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Kastbom, AlfLinköping University,Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linköping University Hospital,Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.;Dept Rheumatol Ostergotland, Linkoping, Sweden.(Swepub:liu)alfka05
(author)
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Larsson, PerAcad Specialist Ctr, Stockholm, Sweden.
(author)
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Uhrenholt, LineAalborg Univ Hosp, Dept Rheumatol, Aalborg, Denmark.,Aalborg University Hospital
(author)
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Just, Soren AndreasOdense Univ Hosp, Dept Rheumatol, Odense, Denmark.;Svendborg Hosp, Dept Med, Sect Rheumatol, Svendborg, Denmark.,Svendborg Hospital,Odense University Hospital
(author)
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Stevens, David J.Univ Hosp Trondheim, St Olavs Hosp, Dept Rheumatol, Trondheim, Norway.,St. Olav’s University Hospital
(author)
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Laurbjerg, Trine BayAarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark.,Aarhus University Hospital
(author)
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Bakland, GunnsteinUniv Hosp Northern Norway, Dept Rheumatol, Tromso, Norway.;Univ Tromso, Dept Rheumatol, Tromso, Norway.,UiT The Arctic University of Norway, Tromsø,University Hospital of North Norway
(author)
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Olsen, Inge ChristofferOslo Univ Hosp, Dept Res Support Clin Trials, Oslo, Norway.,Oslo university hospital
(author)
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Haavardsholm, Espen A.Diakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMEDY, Oslo, Norway.,Diakonhjemmet Hospital
(author)
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Lampa, JonKarolinska Institute,Karolinska University Hospital,Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.
(author)
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Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, DK-2600 Glostrup, Copenhagen, Denmark.;Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.University of Copenhagen
(creator_code:org_t)
Related titles
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In:Annals of the Rheumatic Diseases: BMJ PUBLISHING GROUP82:10, s. 1286-12950003-49671468-2060
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