Sökning: WFRF:(Kapetanovic Meliha Crnkic)
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Certolizumab pegol,...
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis : 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
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- Ostergaard, Mikkel (författare)
- Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, DK-2600 Glostrup, Copenhagen, Denmark.;Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.,University of Copenhagen,Copenhagen University Hospital
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- van Vollenhoven, Ronald F. (författare)
- Karolinska Institute,Amsterdam Univ Med Ctr, Amsterdam Rheumatol & Immunol Ctr, Dept Rheumatol & Clin Immunol, Amsterdam, Netherlands.,Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.
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- Rudin, Anna, 1961 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Hetland, Merete Lund (författare)
- Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.,Copenhagen University Hospital,University of Copenhagen
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- Heiberg, Marte Schrumpf (författare)
- Diakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMEDY, Oslo, Norway.,Diakonhjemmet Hospital
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- Nordstrom, Dan C. (författare)
- Helsinki Univ Hosp, Div Internal Med & Rheumatol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.,Helsinki University Central Hospital
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- Nurmohamed, Michael T. (författare)
- Reade, Locat VUmc, Amsterdam, Netherlands.;Amsterdam Univ Med Ctr, Amsterdam, Netherlands.,Academic Medical Center of University of Amsterdam (AMC)
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- Gudbjornsson, Bjorn (författare)
- Univ Iceland, Landspitali Univ Hosp, Reykjavik, Iceland.;Ctr Rheumatol Res, Dept Rheumatol, Reykjavik, Iceland.,Centre for Rheumatology Research,National University Hospital of Iceland
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- Ornbjerg, Lykke Midtboll (författare)
- Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.,Copenhagen University Hospital
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- Boyesen, Pernille (författare)
- Oslo Univ Hosp, Dept Rheumatol, Oslo, Norway.,Oslo university hospital
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- Lend, Kristina (författare)
- Karolinska Institute,Karolinska Institutet,Academic Medical Center of University of Amsterdam (AMC),Amsterdam Univ Med Ctr, Amsterdam Rheumatol Ctr, Dept Rheumatol & Clin Immunol, Amsterdam, Netherlands.;Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.
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- Horslev-Petersen, Kim (författare)
- Danish Hosp Rheumat Dis, Dept Rheumatol, Sonderborg, Denmark.;Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.,Danish Hospital for Rheumatic Diseases (IRS),University of Southern Denmark
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- Uhlig, Till (författare)
- Diakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMEDY, Oslo, Norway.,Diakonhjemmet Hospital
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- Sokka, Tuulikki (författare)
- Univ Eastern Finland, Jyvaskyla Cent Hosp, Jyvaskyla, Finland.,University of Eastern Finland
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- Grondal, Gerdur (författare)
- Univ Iceland, Landspitali Univ Hosp, Reykjavik, Iceland.,National University Hospital of Iceland
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- Krabbe, Simon (författare)
- Herlev Gentofte Univ Hosp, Dept Radiol, Herlev, Denmark.
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- Lindqvist, Joakim (författare)
- Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.
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- Gjertsson, Inger, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Glinatsi, Daniel (författare)
- Rigshospitalet, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Denmark.;Skaraborg Hosp, Dept Rheumatol, Skovde, Sweden.,Skaraborg Hospital,Copenhagen University Hospital
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- Kapetanovic, Meliha Crnkic (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Lund Univ, Dept Clin Sci, Lund, Sweden.
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- Aga, Anna-Birgitte (författare)
- Diakonhjemmet Hosp, Dept Rheumatol, Oslo, Norway.,Diakonhjemmet Hospital
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- Faustini, Francesca (författare)
- Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.
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- Parmanne, Pinja (författare)
- Helsinki Univ Hosp, Div Internal Med & Rheumatol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.,Helsinki University Central Hospital
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- Lorenzen, Tove (författare)
- Silkeborg Univ Hosp, Dept Rheumatol, Silkeborg, Denmark.,Silkeborg Regional Hospital
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- Giovanni, Cagnotto (författare)
- Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci, Lund, Sweden.;Skane Univ Hosp, Dept Rheumatol, Lund, Sweden.
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- Back, Johan (författare)
- Uppsala Univ Hosp, Dept Med Sci, Uppsala, Sweden.,Uppsala University Hospital
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- Hendricks, Oliver (författare)
- Danish Hosp Rheumat Dis, Dept Rheumatol, Sonderborg, Denmark.;Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.,University of Southern Denmark,Danish Hospital for Rheumatic Diseases (IRS)
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- Vedder, Daisy (författare)
- Reade, Dept Rheumatol, Amsterdam, Netherlands.
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- Rannio, Tuomas (författare)
- Univ Eastern Finland, Jyvaskyla Cent Hosp, Jyvaskyla, Finland.,University of Eastern Finland
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- Grenholm, Emma (författare)
- Dept Rheumatol, Falun, Sweden.,Mälar Hospital
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- Ljosa, Maud Kristine (författare)
- Alesund Hosp, Dept Rheumatol, Alesund, Norway.
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- Brodin, Eli (författare)
- Haukeland Hosp, Dept Rheumatol, Bergen, Norway.,Haukeland University Hospital
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- Lindegaard, Hanne (författare)
- Odense Univ Hosp, Rheumatol Res Unit, Odense, Denmark.,Odense University Hospital
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- Soderbergh, Annika (författare)
- Orebro Univ Hosp, Dept Rheumatol, Orebro, Sweden.,Örebro University Hospital
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- Rizk, Milad (författare)
- Vastmanlands Hosp Vasteras, Dept Rheumatol, Vasteras, Sweden.
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- Kastbom, Alf (författare)
- Linköping University,Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linköping University Hospital,Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.;Dept Rheumatol Ostergotland, Linkoping, Sweden.
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- Larsson, Per (författare)
- Acad Specialist Ctr, Stockholm, Sweden.
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- Uhrenholt, Line (författare)
- Aalborg Univ Hosp, Dept Rheumatol, Aalborg, Denmark.,Aalborg University Hospital
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- Just, Soren Andreas (författare)
- Odense Univ Hosp, Dept Rheumatol, Odense, Denmark.;Svendborg Hosp, Dept Med, Sect Rheumatol, Svendborg, Denmark.,Svendborg Hospital,Odense University Hospital
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- Stevens, David J. (författare)
- Univ Hosp Trondheim, St Olavs Hosp, Dept Rheumatol, Trondheim, Norway.,St. Olav’s University Hospital
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- Laurbjerg, Trine Bay (författare)
- Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark.,Aarhus University Hospital
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- Bakland, Gunnstein (författare)
- Univ Hosp Northern Norway, Dept Rheumatol, Tromso, Norway.;Univ Tromso, Dept Rheumatol, Tromso, Norway.,UiT The Arctic University of Norway, Tromsø,University Hospital of North Norway
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- Olsen, Inge Christoffer (författare)
- Oslo Univ Hosp, Dept Res Support Clin Trials, Oslo, Norway.,Oslo university hospital
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- Haavardsholm, Espen A. (författare)
- Diakonhjemmet Hosp, Ctr Treatment Rheumat & Musculoskeletal Dis REMEDY, Oslo, Norway.,Diakonhjemmet Hospital
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- Lampa, Jon (författare)
- Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Ctr Mol Med, Dept Med, Rheumatol Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.
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Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, DK-2600 Glostrup, Copenhagen, Denmark;Rigshospitalet, Copenhagen Ctr Arthrit Res, Ctr Rheumatol & Spine Dis, Ctr Head & Orthopaed, Glostrup, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark. University of Copenhagen (creator_code:org_t)
- BMJ PUBLISHING GROUP, 2023
- 2023
- Engelska.
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Ingår i: Annals of the Rheumatic Diseases. - : BMJ PUBLISHING GROUP. - 0003-4967 .- 1468-2060. ; 82:10, s. 1286-1295
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with different modes of action. Methods Investigator-initiated, randomised, blinded-assessor study. Patients with treatment-naive early RA with moderate-severe disease activity were randomised 1:1:1:1 to methotrexate combined with (1) active conventional therapy: oral prednisolone (tapered quickly, discontinued at week 36) or sulfasalazine, hydroxychloroquine and intra-articular glucocorticoid injections in swollen joints; (2) certolizumab pegol; (3) abatacept or (4) tocilizumab. Coprimary endpoints were week 48 Clinical Disease Activity Index (CDAI) remission (CDAI <= 2.8) and change in radiographic van der Heijde-modified Sharp Score, estimated using logistic regression and analysis of covariance, adjusted for sex, anticitrullinated protein antibody status and country. Bonferroni's and Dunnet's procedures adjusted for multiple testing (significance level: 0.025). Results Eight hundred and twelve patients were randomised. Adjusted CDAI remission rates at week 48 were: 59.3% (abatacept), 52.3% (certolizumab), 51.9% (tocilizumab) and 39.2% (active conventional therapy). Compared with active conventional therapy, CDAI remission rates were significantly higher for abatacept (adjusted difference +20.1%, p<0.001) and certolizumab (+13.1%, p=0.021), but not for tocilizumab (+12.7%, p=0.030). Key secondary clinical outcomes were consistently better in biological groups. Radiographic progression was low, without group differences. Conclusions Compared with active conventional therapy, clinical remission rates were superior for abatacept and certolizumab pegol, but not for tocilizumab. Radiographic progression was low and similar between treatments.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Rheumatoid Arthritis
- Certolizumab pegol
- Abatacept
- Methotrexate
- Biological Therapy
- Abatacept
- Biological Therapy
- Certolizumab pegol
- Methotrexate
- Rheumatoid Arthritis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Ostergaard, Mikk ...
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van Vollenhoven, ...
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Rudin, Anna, 196 ...
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Hetland, Merete ...
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Heiberg, Marte S ...
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Nordstrom, Dan C ...
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visa fler...
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Nurmohamed, Mich ...
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Gudbjornsson, Bj ...
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Ornbjerg, Lykke ...
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Boyesen, Pernill ...
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Lend, Kristina
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Horslev-Petersen ...
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Uhlig, Till
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Sokka, Tuulikki
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Grondal, Gerdur
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Krabbe, Simon
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Lindqvist, Joaki ...
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Gjertsson, Inger ...
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Glinatsi, Daniel
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Kapetanovic, Mel ...
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Aga, Anna-Birgit ...
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Faustini, France ...
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Parmanne, Pinja
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Lorenzen, Tove
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Giovanni, Cagnot ...
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Back, Johan
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Hendricks, Olive ...
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Vedder, Daisy
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Rannio, Tuomas
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Grenholm, Emma
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Ljosa, Maud Kris ...
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Brodin, Eli
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Lindegaard, Hann ...
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Soderbergh, Anni ...
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Rizk, Milad
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Kastbom, Alf
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Larsson, Per
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Uhrenholt, Line
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Just, Soren Andr ...
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Stevens, David J ...
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Laurbjerg, Trine ...
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Bakland, Gunnste ...
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Olsen, Inge Chri ...
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Haavardsholm, Es ...
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Lampa, Jon
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Immunologi inom ...
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Annals of the Rh ...
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Uppsala universitet
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Linköpings universitet
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Karolinska Institutet
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Lunds universitet
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Göteborgs universitet