SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Vernooij Meike W.)
 

Search: WFRF:(Vernooij Meike W.) > (2020-2024) > Neuroimaging in Dem...

Neuroimaging in Dementia : More than Typical Alzheimer Disease

Haller, Sven (author)
Uppsala universitet,Radiologi
Jäger, Hans Rolf (author)
Vernooij, Meike W (author)
show more...
Barkhof, Frederik (author)
show less...
 (creator_code:org_t)
Radiological Society of North America (RSNA), 2023
2023
English.
In: Radiology. - : Radiological Society of North America (RSNA). - 0033-8419 .- 1527-1315. ; 308:3
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Alzheimer disease (AD) is the most common cause of dementia. The prevailing theory of the underlying pathology assumes amyloid accumulation followed by tau protein aggregation and neurodegeneration. However, the current antiamyloid and antitau treatments show only variable clinical efficacy. Three relevant points are important for the radiologic assessment of dementia. First, besides various dementing disorders (including AD, frontotemporal dementia, and dementia with Lewy bodies), clinical variants and imaging subtypes of AD include both typical and atypical AD. Second, atypical AD has overlapping radiologic and clinical findings with other disorders. Third, the diagnostic process should consider mixed pathologies in neurodegeneration, especially concurrent cerebrovascular disease, which is frequent in older age. Neuronal loss is often present at, or even before, the onset of cognitive decline. Thus, for effective emerging treatments, early diagnosis before the onset of clinical symptoms is essential to slow down or stop subsequent neuronal loss, requiring molecular imaging or plasma biomarkers. Neuroimaging, particularly MRI, provides multiple imaging parameters for neurodegenerative and cerebrovascular disease. With emerging treatments for AD, it is increasingly important to recognize AD variants and other disorders that mimic AD. Describing the individual composition of neurodegenerative and cerebrovascular disease markers while considering overlapping and mixed diseases is necessary to better understand AD and develop efficient individualized therapies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

  • Radiology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor
Haller, Sven
Jäger, Hans Rolf
Vernooij, Meike ...
Barkhof, Frederi ...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Neurosciences
Articles in the publication
Radiology
By the university
Uppsala University

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view