Sökning: WFRF:(Ramachandran Mohanraj) >
Of mice and lymphoi...
Of mice and lymphoid aggregates : modeling tertiary lymphoid structures in cancer
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- Vaccaro, Alessandra (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
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- van de Walle, Tiarne (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi,Cancerimmunterapi
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- Ramachandran, Mohanraj, 1988- (författare)
- Uppsala universitet,Vaskulärbiologi,Science for Life Laboratory, SciLifeLab,Cancerimmunterapi
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- Essand, Magnus (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerimmunterapi
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- Dimberg, Anna (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Vaskulärbiologi
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(creator_code:org_t)
- Frontiers Media S.A. 2023
- 2023
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 14
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized into B and T cell zones, and are not encapsulated but include all cell types necessary for eliciting an adaptive immune response. TLS have been observed in various cancer types and are generally associated with a positive prognosis as well as increased sensitivity to cancer immunotherapy. However, a comprehensive understanding of the roles of TLS in eliciting anti-tumor immunity as well as the mechanisms involved in their formation and function is still lacking. Further studies in orthotopic, immunocompetent cancer models are necessary to evaluate the influence of TLS on cancer therapies, and to develop new treatments that promote their formation in cancer. Here, we review key insights obtained from functional murine studies, discuss appropriate models that can be used to study cancer-associated TLS, and suggest guidelines on how to identify TLS and distinguish them from other antigen-presenting niches.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- tertiary lymphoid structures
- murine models
- cancer
- immunotherapy
- antigen-presenting niches
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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