Development of a simple paste for 3D printing of drug formulations containing a mesoporous material loaded with a poorly water-soluble drug

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Katsiotis, Christos S.Uppsala universitet,Nanoteknologi och funktionella material (author)

Development of a simple paste for 3D printing of drug formulations containing a mesoporous material loaded with a poorly water-soluble drug

Article/chapterEnglish2024

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Elsevier,2024
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LIBRIS-ID:oai:DiVA.org:uu-523789
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523789URI
https://doi.org/10.1016/j.ejpb.2024.114270DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Poorly soluble drugs represent a substantial portion of emerging drug candidates, posing significant challenges for pharmaceutical formulators. One promising method to enhance the drug’s dissolution rate and, consequently, bioavailability involves transforming them into an amorphous state within mesoporous materials. These materials can then be seamlessly integrated into personalized drug formulations using Additive Manufacturing (AM) techniques, most commonly via Fused Deposition Modeling. Another innovative approach within the realm of AM for mesoporous material-based formulations is semi-solid extrusion (SSE). This study showcases the feasibility of a straightforward yet groundbreaking hybrid 3D printing system employing SSE to incorporate drug-loaded mesoporous magnesium carbonate (MMC) into two different drug formulations, each designed for distinct administration routes. MMC was loaded with the poorly water-soluble drug ibuprofen via a solvent evaporation method and mixed with PEG 400 as a binder and lubricant, facilitating subsequent SSE. The formulation is non-aqueous, unlike most pastes which are used for SSE, and thus is beneficial for the incorporation of poorly water-soluble drugs. The 3D printing process yielded tablets for oral administration and suppositories for rectal administration, which were then analyzed for their dissolution behavior in biorelevant media. These investigations revealed enhancements in the dissolution kinetics of the amorphous drug-loaded MMC formulations. Furthermore, an impressive drug loading of 15.3 % w/w of the total formulation was achieved, marking the highest reported loading for SSE formulations incorporating mesoporous materials to stabilize drugs in their amorphous state by a wide margin. This simple formulation containing PEG 400 also showed advantages over other aqueous formulations for SSE in that the formulations did not exhibit weight loss or changes in size or form during the curing process post-printing. These results underscore the substantial potential of this innovative hybrid 3D printing system for the development of drug dosage forms, particularly for improving the release profile of poorly water-soluble drugs.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
TEKNIK OCH TEKNOLOGIER Materialteknik Annan materialteknik hsv//swe
ENGINEERING AND TECHNOLOGY Materials Engineering Other Materials Engineering hsv//eng
3D printing
Additive manufacturing
Semi Solid Extrusion
Paste
Mesoporous Magnesium Carbonate
Poorly soluble drug
Drug delivery
Engineering Science with specialization in Nanotechnology and Functional Materials
Teknisk fysik med inriktning mot nanoteknologi och funktionella material

Added entries (persons, corporate bodies, meetings, titles ...)

Tikhomirov, EvgeniiUppsala universitet,Nanoteknologi och funktionella material(Swepub:uu)evgti953 (author)
Leliopoulos, ChristosUppsala universitet,Makromolekylär kemi(Swepub:uu)chrle669 (author)
Strømme, Maria,1970-Uppsala universitet,Nanoteknologi och funktionella material(Swepub:uu)mst26208 (author)
Welch, Ken,1968-Uppsala universitet,Nanoteknologi och funktionella material(Swepub:uu)kewel087 (author)
Uppsala universitetNanoteknologi och funktionella material (creator_code:org_t)

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In:European journal of pharmaceutics and biopharmaceutics: Elsevier1980939-64111873-3441

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