Sökning: id:"swepub:oai:DiVA.org:uu-524291" >
SpotLight Proteomic...
-
Wang, JijingKarolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
(författare)
SpotLight Proteomics Identifies Variable Sequences of Blood Antibodies Specific Against Deamidated Human Serum Albumin
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
-
Elsevier,2023
-
electronicrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-524291
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524291URI
-
https://doi.org/10.1016/j.mcpro.2023.100589DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:237301377URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:154929367URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Spontaneous deamidation of asparaginyl residues in proteins, if not repaired or cleared, can set in motion a cascade that leads to deteriorated health. Previously, we have discovered that deamidated human serum albumin (HSA) is elevated in the blood of patients with Alzheimer's disease and other neurodegenerative diseases, while the level of endogenous antibodies against deamidated HSA is significantly diminished, creating an imbalance between the risk factor and the defense against it. Endogenous antibodies against deamidated proteins are still unexplored. In the current study, we employed the SpotLight proteomics approach to identify novel amino acid sequences in antibodies specific to deamidated HSA. The results provide new insights into the clearance mechanism of deamidated proteins, a possible avenue for prevention of neurodegeneration.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Lundström, Susanna L.Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
(författare)
-
Lu, WeiqiKarolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.;Xi An Jiao Tong Univ, Dept Ophthalmol, Affiliated Hosp 1, Xian, Peoples R China.
(författare)
-
Huang, YiqiKarolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.;Tech Univ Munich, Inst Virol, Sch Med, Munich, Germany.
(författare)
-
Rodin, SergeyUppsala universitet,Thoraxkirurgi,Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.(Swepub:uu)serro142
(författare)
-
Zubarev, Roman A.Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
(författare)
-
Karolinska InstitutetKarolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Molecular & Cellular Proteomics: Elsevier22:71535-94761535-9484
Internetlänk
Hitta via bibliotek
Till lärosätets databas