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Treatment-free remi...
Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial.
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- Flygt, Hjalmar (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Science and Division of Hematology, Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden
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- Söderlund, Stina (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Department of Medical Science and Division of Hematology, Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden
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- Richter, Johan (author)
- Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Sweden
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- Saussele, Susanne (author)
- Medical Clinic, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany,Heidelberg Univ, Germany
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- Koskenvesa, Perttu (author)
- Department of Hematology, Hematology Research Unit Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland,Hematol Res Unit Helsinki, Finland; Helsinki Univ Hosp, Finland
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- Stenke, Leif (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Mustjoki, Satu (author)
- Department of Hematology, Hematology Research Unit Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland; ICAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland,Hematol Res Unit Helsinki, Finland; Helsinki Univ Hosp, Finland; Univ Helsinki, Finland; Univ Helsinki, Finland; ICAN Digital Precis Canc Med Flagship, Finland
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- Dimitrijevic, Andreja (author)
- Department of Hematology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark
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- Stentoft, Jesper (author)
- Department of Hematology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark
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- Majeed, Waleed (author)
- Department of Hemato-Oncology, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Norway
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- Roy, Lydia (author)
- French CML group Fi-LMC, Centre Léon Bérard, Lyon, Hôpital Universitaire Henri Mondor, AP-HP, Service d'hématologie Clinique & Faculté de Santé, Université Paris Est Créteil, Créteil, France,Univ Paris Est Creteil, France; Univ Paris Est Creteil, France
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- Wolf, Dominik (author)
- Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI), Tyrolean Cancer Research Institute (TKFI), Medical University Innsbruck, Innsbruck, Austria; Medical Clinic 3, Universitätsklinikum, Bonn, Germany,Med Univ Innsbruck, Austria; Univ Klinikum Bonn, Germany
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- Dreimane, Arta (author)
- Department of Hematology, Linköping University Hospital, Linköping, Sweden,Region Östergötland, Hematologiska kliniken US
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- Gjertsen, Bjørn Tore (author)
- Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway,Haukeland Hosp, Norway
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- Gedde-Dahl, Tobias (author)
- Department of Hematology, Oslo University Hospital, Rikshospitalet, Oslo, Norway,Natl Hosp Norway, Norway
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- Ahlstrand, Erik, 1974- (author)
- Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Medicine,Orebro Univ, Sweden
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- Markevärn, Berit (author)
- Department of Hematology, Umeå University Hospital, Umeå, Sweden,Umea Univ Hosp, Sweden
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- Hjorth-Hansen, Henrik (author)
- Department of Hematology, St. Olavs Hospital, Trondheim, Norway,St Olavs Hosp, Norway
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- Janssen, Jeroen (author)
- Department of Hematology, Radboud University medical center, Nijmegen, The Netherlands,Radboud Univ Nijmegen, Netherlands
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- Olsson-Strömberg, Ulla (author)
- Department of Medical Science and Division of Hematology, Uppsala University Hospital, Uppsala, Sweden,Uppsala Univ Hosp, Sweden
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Leukemia. - : Springer. - 0887-6924 .- 1476-5551.
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tyrosine kinase inhibitor (TKI) discontinuation in chronic myeloid leukemia (CML) has become part of routine care for patients with a sustained deep molecular response (DMR). Approximately 50% experience a molecular relapse upon TKI cessation. Most of them quickly regain DMR upon TKI resumption. Whether these patients can achieve a second treatment-free remission (TFR) remains unclear. DAstop2 (ClinicalTrials.gov ID: NCT03573596) is a prospective study including patients with a failed first TFR attempt re-treated with any TKI for ≥ one year. Upon entering the study, patients received the TKI dasatinib for additional two years. Patients with sustained DMR for ≥1 year qualified for a second TKI stop. Ninety-four patients were included between Oct 2017-Dec 2021. At the time of data analysis, 62 patients had attempted a 2nd stop. After a median follow-up of 27 months from 2nd stop, TFR rates were 61, 56 and 46% at 6, 12 and 24 months respectively. No progression to advanced stage disease was seen and 87% had re-achieved MR4 within a median of 3 months from TKI re-initiation. In summary, we show that a 2nd TFR attempt after dasatinib treatment is safe, feasible and TFR rates seem in the range of those reported in trials of a first TKI stop.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Medicinsk vetenskap
- Medical Science
Publication and Content Type
- ref (subject category)
- art (subject category)
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Leukemia
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To the university's database
- By the author/editor
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Flygt, Hjalmar
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Söderlund, Stina
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Richter, Johan
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Saussele, Susann ...
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Koskenvesa, Pert ...
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Stenke, Leif
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Mustjoki, Satu
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Dimitrijevic, An ...
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Stentoft, Jesper
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Majeed, Waleed
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Roy, Lydia
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Wolf, Dominik
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Dreimane, Arta
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Gjertsen, Bjørn ...
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Gedde-Dahl, Tobi ...
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Ahlstrand, Erik, ...
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Markevärn, Berit
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Hjorth-Hansen, H ...
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Janssen, Jeroen
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Olsson-Strömberg ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Leukemia
- By the university
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Uppsala University
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Örebro University
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Karolinska Institutet
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Linköping University