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  • Maranesi, MargheritaUniv Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy. (författare)

Resistin in endocrine pancreas of sheep : Presence and expression related to different diets

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-524639
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524639URI
  • https://doi.org/10.1016/j.ygcen.2024.114452DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Resistin (RETN), a recently discovered adipokine, is a cysteine-rich and secretory protein produced by adipocytes. RETN has been detected in several tissues, including human and laboratory animals' pancreas, wherein impairs glucose tolerance and insulin (INS) action and causes INS resistance. This study aims to evaluate the presence and expression of RETN in the pancreas of 15 adult female sheep reared on Apennine pastures, which show a decrease in their nutritional value due to the drought stress linked to the increasing summer aridity. The sheep were divided into 3 groups according to the diet they were subjected to: maximum pasture flowering (MxF) group, maximum pasture dryness (MxD) group, and experimental (Exp) group which received a feed supplementation in addition to the MxD group feeding. Immunohistochemistry and immunofluorescence were performed on formalin-fixed and paraffin-embedded sections of the pancreas to detect the RETN presence and to evaluate the co-localization of RETN with both glucagon (GCG)- and INS-producing cells. In addition, the expression of the three molecules was evaluated also in relation to different diets. RETN was observed only in the endocrine pancreas, showing a wide distribution throughout the pancreatic islets with few negative cells and the RETN producing cells colocalized with both alpha cells and ss cells. No differences in distribution and immunostaining intensity of RETN, GCG and INS were observed among the three groups. Quantitative PCR showed the expression of RETN, GCG and INS in all tested samples. No significant differences were observed for RETN and GCG among all three groups of sheep. Instead, a high statistically significant expression of INS was detected in the MxF group with respect to the Exp and MxD groups. These results highlight the localization of RETN in GCG- and INS-secreting cells involved in glucose homeostasis suggesting a modulatory role for RETN. Furthermore, the RETN expression is not influenced by food supplementation and thus is not affected by diet.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Palmioli, ElisaUniv Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy.;Dept Philosophy Social Sci & Educ, PhD Course Ethics Commun Sci Res, PhD Course Ethics Commun Sci Res & Technol Innovat, Piazza G Ermini 1, I-06123 Perugia, IT, Italy. (författare)
  • Dall'Aglio, CeciliaUniv Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy. (författare)
  • Marini, DanieleUppsala universitet,Fysiologi och miljötoxikologi,Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy.(Swepub:uu)danma891 (författare)
  • Anipchenko, PolinaUniv Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy. (författare)
  • De Felice, ElenaUniv Camerino, Sch Biosci & Vet Med, Via Pontoni 5, IT-62032 Camerino, IT, Italy. (författare)
  • Scocco, PaolaUniv Camerino, Sch Biosci & Vet Med, Via Pontoni 5, IT-62032 Camerino, IT, Italy. (författare)
  • Mercati, FrancescaUniv Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy. (författare)
  • Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy.Univ Perugia, Dept Vet Med, Via San Costanzo 4, I-06126 Perugia, IT, Italy.;Dept Philosophy Social Sci & Educ, PhD Course Ethics Commun Sci Res, PhD Course Ethics Commun Sci Res & Technol Innovat, Piazza G Ermini 1, I-06123 Perugia, IT, Italy. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:General and Comparative Endocrinology: Elsevier3480016-64801095-6840

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