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  • Li, YachenWuhan Univ Sci & Technol, Inst Social Dev & Hlth Management, Sch Publ Hlth, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China. (författare)

Intrauterine and early postnatal exposures to submicron particulate matter and childhood allergic rhinitis : A multicity cross-sectional study in China

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-524641
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-524641URI
  • https://doi.org/10.1016/j.envres.2024.118165DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Airborne particulate matter pollution has been linked to occurrence of childhood allergic rhinitis (AR). However, the relationships between exposure to particulate matter with an aerodynamic diameter <= 1 µm (PM1) during early life (in utero and first year of life) and the onset of childhood AR remain largely unknown. This study aims to investigate potential associations of in utero and first-year exposures to size-segregated PMs, including PM1, PM1-2.5, PM2.5, PM2.5-10, and PM10, with childhood AR.Methods: We investigated 29286 preschool children aged 3-6 years in 7 Chinese major cities during 2019-2020 as the Phase II of the China Children, Families, Health Study. Machine learning-based space-time models were utilized to estimate early-life residential exposure to PM1, PM2.5, and PM10 at 1 x 1-km resolutions. The concentrations of PM1-2.5 and PM2.5-10 were calculated by subtracting PM1 from PM2.5 and PM2.5 from PM10, respectively. Multiple mixed-effects logistic models were used to assess the odds ratios (ORs) and 95% confidence intervals (CIs) of childhood AR associated with per 10-µg/m3 increase in exposure to particulate air pollution during in utero period and the first year of life.Results: Among the 29286 children surveyed (mean +/- standard deviation, 4.9 +/- 0.9 years), 3652 (12.5%) were reported to be diagnosed with AR. Average PM1 concentrations during in utero period and the first year since birth were 36.3 +/- 8.6 µg/m3 and 33.1 +/- 6.9 µg/m3, respectively. Exposure to PM1 and PM2.5 during pregnancy and the first year of life was associated with an increased risk of AR in children, and the OR estimates were higher for each 10-µg/m3 increase in PM1 than for PM2.5 (e.g., 1.132 [95% CI: 1.022-1.254] vs. 1.079 [95% CI: 1.014-1.149] in pregnancy; 1.151 [95% CI: 1.014-1.306] vs. 1.095 [95% CI: 1.008-1.189] in the first year of life). No associations were observed between AR and both pre- and post-natal exposure to PM1-2.5, indicating that PM1 rather than PM1-2.5 contributed to the association between PM2.5 and childhood AR. In trimester-stratified analysis, childhood AR was only found to be associated with exposure to PM1 (OR = 1.077, 95% CI: 1.027-1.128), PM2.5 (OR = 1.048, 95% CI: 1.018-1.078), and PM10 (OR = 1.032, 95% CI: 1.007-1.058) during the third trimester of pregnancy. Subgroup analysis suggested stronger PM-AR associations among younger (<5 years old) and winter-born children.Conclusions: Prenatal and postnatal exposures to ambient PM1 and PM2.5 were associated with an increased risk of childhood AR, and PM2.5-related hazards could be predominantly attributed to PM1. These findings highlighted public health significance of formulating air quality guideline for ambient PM1 in mitigating children's AR burden caused by particulate air pollution.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhu, LifengWuhan Univ Sci & Technol, Inst Social Dev & Hlth Management, Sch Publ Hlth, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China. (författare)
  • Wei, JingUniv Maryland, Earth Syst Sci Interdisciplinary Ctr, Dept Atmospher & Ocean Sci, College Pk, MD 20740 USA. (författare)
  • Wu, ChuanshaWuhan Univ Sci & Technol, Sch Publ Hlth, Dept Environm Hyg & Occupat Med, Wuhan 430065, Peoples R China. (författare)
  • Zhao, ZhuohuiFudan Univ, Sch Publ Hlth, Dept Environm Hlth, Shanghai 200030, Peoples R China. (författare)
  • Norbäck, DanUppsala universitet,Arbets- och miljömedicin(Swepub:uu)dagnorba (författare)
  • Zhang, XinShanxi Univ, Res Ctr Environm Sci & Engn, Taiyuan 030006, Peoples R China. (författare)
  • Lu, ChanCent South Univ, Xiangya Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Peoples R China. (författare)
  • Yu, WeiChongqing Univ, Joint Int Res Lab Green Bldg & Built Environm, Minist Educ, Chongqing 400045, Peoples R China. (författare)
  • Wang, TingtingShanghai Univ Med & Hlth Sci, Sch Nursing & Hlth Management, Shanghai 201318, Peoples R China. (författare)
  • Zheng, XiaohongSoutheast Univ, Sch Energy & Environm, Nanjing 210096, Peoples R China. (författare)
  • Zhang, LingWuhan Univ Sci & Technol, Sch Publ Hlth, Dept Environm Hyg & Occupat Med, Wuhan 430065, Peoples R China. (författare)
  • Zhang, YunquanWuhan Univ Sci & Technol, Inst Social Dev & Hlth Management, Sch Publ Hlth, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China.;Wuhan Univ Sci & Technol, Sch Publ Hlth, 2 Huangjiahu West Rd,Qingling St, Wuhan 430065, Peoples R China. (författare)
  • Wuhan Univ Sci & Technol, Inst Social Dev & Hlth Management, Sch Publ Hlth, Hubei Prov Key Lab Occupat Hazard Identificat & Co, Wuhan 430065, Peoples R China.Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, Dept Atmospher & Ocean Sci, College Pk, MD 20740 USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Environmental Research: Elsevier2470013-93511096-0953

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