Search: WFRF:(Nilsson Elisabet M)
> (2020-2024) >
Anti-histone and an...
Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish Systemic Lupus Erythematosus patients.
-
- Elbagir, Sahwa (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
-
- Mohammed, NasrEldeen A (author)
- Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.,Al Neelain Univ, Sudan
-
- Oke, Vilija (author)
- Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.,Karolinska Inst, Sweden; Acad Specialist Ctr, Sweden
-
show more...
-
- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi,Uppsala Univ, Sweden
-
- Nilsson, Jan (author)
- Department of Experimental Medical Science, Lund University, Lund, Sweden.,Lund Univ, Sweden
-
- Elshafie, Amir (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Region Östergötland, Klinisk immunologi och transfusionsmedicin,Uppsala Univ, Sweden
-
- Elagib, Elnour M (author)
- Rheumatology unit, Alribat University Hospital, Khartoum, Sudan.,Mil Hosp, Sudan
-
- Nur, Musa A M (author)
- Rheumatology unit, Alribat University Hospital, Khartoum, Sudan.,Alribat Univ Hosp, Sudan
-
- Gunnarsson, Iva (author)
- Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
-
- Svenungsson, Elisabet (author)
- Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.,Karolinska Inst, Sweden
-
- Rönnelid, Johan (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ, Sweden
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Rheumatology. - : OXFORD UNIV PRESS. - 1462-0324 .- 1462-0332.
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVES: In SLE, anti-dsDNA can co-occur with autoantibodies against other chromatin components, like histones and nucleosomes. These antibodies induce type-1 interferon production, a hallmark of SLE. We measured antinuclear antibody (ANA) sub-specificities and investigated their associations to inflammatory biomarkers including interferon-regulated chemokines.METHODS: We included 93 Sudanese and 480 Swedish SLE patients and matched controls (N = 104 + 192). Autoantibodies targeting ANA-subspecificites: dsDNA, Sm, Sm/U1RNPcomplex, U1RNP, SSA/Ro52, SSA/Ro60, SSB/La, ribosomal P, PCNA and histones were quantified in all subjects, anti-nucleosome only in the Swedish patients, with a bead-based multiplex immunoassay. Levels of 72 plasma biomarkers were determined with Proximity Extension Assay technique or ELISA.RESULTS: Among Sudanese patients, the investigated antibodies significantly associated with 9/72 biomarkers. Anti-histone antibodies showed the strongest positive correlations with MCP-3 and S100A12 as well as with interferon I-inducible factors MCP-1 and CXCL10. Anti-dsDNA antibodies associated with CXCL10 and S100A12, but in multivariate analyses, unlike anti-histone, associations lost significance.Among Swedish patients, MCP-1, CXCL10, SA100A12 also demonstrated stronger associations to anti-histone and anti-nucleosome antibodies, compared with anti-dsDNA and other ANA sub-specificities. In multiple regression models, anti-histone/nucleosome retained the strongest associations. When excluding anti-histone or anti-nucleosome positive patients, the associations between MCP-1/CXCL10 and anti-dsDNA were lost. In contrast, when excluding anti-dsDNA positive patients, associations with anti-histone and anti-nucleosome remained significant.CONCLUSION: In two cohorts of different ethnical origin, autoantibodies targeting chromatin correlate stronger with IFN-induced inflammatory biomarkers than anti-dsDNA or other ANA sub-specificities. Our results suggest that anti-histone/nucleosome autoantibodies may be main drivers of type-1 interferon activity in SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Africa
- Anti-chromatin antibodies
- SLE
- anti-dsDNA
- interferon
- proteome analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Elbagir, Sahwa
-
Mohammed, NasrEl ...
-
Oke, Vilija
-
Larsson, Anders
-
Nilsson, Jan
-
Elshafie, Amir
-
show more...
-
Elagib, Elnour M
-
Nur, Musa A M
-
Gunnarsson, Iva
-
Svenungsson, Eli ...
-
Rönnelid, Johan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Rheumatology
- By the university
-
Uppsala University
-
Linköping University