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Therapeutic hypothe...
Therapeutic hypothermia after perinatal asphyxia in Vietnam : medium-term outcomes at 18 months - a prospective cohort study
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- Tran, Hang Thi Thanh (author)
- Karolinska Institutet
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- Le, Ha Thi (author)
- Vietnam Natl Childrens Hosp, Neonatal Care Ctr, Hanoi, Vietnam.
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- Tran, Dien Minh (author)
- Vietnam Natl Childrens Hosp, Hanoi, Vietnam.
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- Nguyen, Giang Thi Huong (author)
- Vietnam Natl Childrens Hosp, Dept Rehabillitat, Hanoi, Vietnam.
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- Hellström-Westas, Lena, 1954- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Alfven, Tobias (author)
- Karolinska Institutet,Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.;Sachs Children & Youth Hosp, Stockholm, Sweden.
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- Olson, Linus (author)
- Karolinska Institutet
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Karolinska Institutet Vietnam Natl Childrens Hosp, Neonatal Care Ctr, Hanoi, Vietnam (creator_code:org_t)
- BMJ Publishing Group Ltd, 2024
- 2024
- English.
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In: BMJ Paediatrics Open. - : BMJ Publishing Group Ltd. - 2399-9772. ; 8:1
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Aim To determine neurodevelopmental outcome at 18 months after therapeutic hypothermia for hypoxic-ischaemic encephalopathy (HIE) infants in Vietnam, a low-middle-income country. Method Prospective cohort study investigating outcomes at 18 months in severely asphyxiated outborn infants who underwent therapeutic hypothermia for HIE in Hanoi, Vietnam, during the time period 2016-2019. Survivors were examined at discharge and at 6 and 18 months by a neonatologist, a neurologist and a rehabilitation physician, who were blinded to the infants' clinical severity during hospitalisation using two assessment tools: the Ages and Stages Questionnaire (ASQ) and the Hammersmith Infant Neurological Examination (HINE), to detect impairments and promote early interventions for those who require it. Results In total, 130 neonates, 85 (65%) with moderate and 45 (35%) with severe HIE, underwent therapeutic hypothermia treatment using phase change material. Forty-three infants (33%) died during hospitalisation and in infancy. Among the 87 survivors, 69 (79%) completed follow-up until 18 months. Nineteen children developed cerebral palsy (8 diplegia, 3 hemiplegia, 8 dyskinetic), and 11 had delayed neurodevelopment. At each time point, infants with a normal or delayed neurodevelopment had significantly higher ASQ and HINE scores (p<0.05) than those with cerebral palsy. Conclusion The rates of mortality and adverse neurodevelopment rate were high and comparable to recently published data from other low-middle-income settings. The ASQ and HINE were useful tools for screening and evaluation of neurodevelopment and neurological function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- neurology
- rehabilitation
- neonatology
Publication and Content Type
- ref (subject category)
- art (subject category)
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