SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Hess Andreas)
 

Search: WFRF:(Hess Andreas) > (2020-2024) > B-cell receptor rea...

  • Thurner, LorenzSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)

B-cell receptor reactivity against Rothia mucilaginosa in nodular lymphocyte-predominant Hodgkin lymphoma

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Ferrata Storti Foundation,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-525069
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-525069URI
  • https://doi.org/10.3324/haematol.2023.282698DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antigen RpoC and its superantigen MID/hag, associated with extralong CDR3 and HLA-DRB1*04 or HLA-DRB1*07 haplotype. The aim of the present study was to extend the antigen screening to further bacteria and viruses. The fragment antibody-binding (Fab) regions of seven new and 15 previously reported cases were analyzed. The reactivity of non-Moraxella spp.-reactive Fab regions against lysates of Rothia mucilaginosa was observed in 5/22 (22.7%) cases. Galactofuranosyl transferase (Gltf) and 2,3-butanediol dehydrogenase (Bdh) of R. mucilaginosa were identified by comparative silver-and immuno-staining in two-dimensional gels, with subsequent mass spectrometry and validation by western blots and enzyme-linked immunosorbent assay. Both R. mucilaginosa Gltf and Bdh induced BCR pathway activation and proliferation in vitro. Apoptosis was induced by recombinant Gltf/ETA'-immunotoxin conjugates in DEV cells expressing recombinant R. mucilaginosa-reactive BCR. Reactivity against M. catarrhalis RpoC was confirmed in 3/7 newly expressed BCR (total 10/22 reactive to Moraxella spp.), resulting in 15/22 (68.2%) cases with BCR reactivity against defined bacterial antigens. These findings strengthen the hypothesis of bacterial trigger contributing to subsets of NLPHL.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fadle, NatalieSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Regitz, EviSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Roth, SophieSaarland Univ, Inst Med Microbiol & Hyg, Homburg, Germany. (author)
  • Cetin, OnurSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Kos, Igor AgeSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Hess, Simon MauroSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Bein, JuliaGoethe Univ Frankfurt Main, Dr Senckenberg Inst Pathol, Frankfurt, Germany. (author)
  • Bohle, Rainer MariaSaarland Univ, Inst Pathol, Med Sch, Homburg, Saar, Germany. (author)
  • Vornanen, MartineTampere Univ Hosp, Dept Pathol, Tampere, Finland.;Univ Tampere, Tampere, Finland. (author)
  • Sundström, ChristerUppsala universitet,Cancerimmunterapi(Swepub:uu)chrisund (author)
  • de Leval, LaurenceLausanne Univ Hosp, Dept Lab Med & Pathol, Lausanne, Switzerland.;Lausanne Univ, Lausanne, Switzerland. (author)
  • Tiacci, EnricoUniv Perugia, Osped S Maria Misericordia, Inst Hematol, Perugia, Italy.;Univ Perugia, Dept Med, Perugia, Italy. (author)
  • Borchmann, PeterUniv Perugia, Osped S Maria Misericordia, Inst Hematol, Perugia, Italy.;Univ Perugia, Dept Med, Perugia, Italy. (author)
  • Engert, AndreasUniv Cologne, Ctr Integrated Oncol Aachen Bonn Cologne Dusseldor, Dept Internal Med 1, Cologne, Germany. (author)
  • Poeschel, ViolaSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Held, GerhardWestpfalz Klinikum, Dept Internal Med 1, Kaiserslautern, Germany. (author)
  • Schwarz, Eva C.Saarland Univ, Med Fac, Ctr Integrat Physiol & Mol Med, Dept Biophys, Homburg, Germany. (author)
  • Neumann, FrankSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Preuss, Klaus -DieterSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Hoth, MarkusSaarland Univ, Med Fac, Ctr Integrat Physiol & Mol Med, Dept Biophys, Homburg, Germany. (author)
  • Kueppers, RalfUniv Duisburg Essen, Inst Cell Biol Canc Res, Med Sch, Essen, Germany.;Deutsch Konsortium Translationale Krebsforschung D, Berlin, Germany. (author)
  • Lehmann, KarolaProteome Factory AG, Berlin, Germany. (author)
  • Hansmann, Martin-LeoFrankfurt Inst Adv Studies, Frankfurt, Germany.;Helios Univ Hosp, Inst Pathol & Mol Pathol, Wuppertal, Germany. (author)
  • Becker, Soeren L.Saarland Univ, Inst Med Microbiol & Hyg, Homburg, Germany. (author)
  • Bewarder, MoritzSaarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany. (author)
  • Hartmann, SylviaGoethe Univ Frankfurt Main, Dr Senckenberg Inst Pathol, Frankfurt, Germany. (author)
  • Saarland Univ, Jose Carreras Ctr Immuno & Gene Therapy & Internal, Med Sch, Homburg, Saar, Germany.Saarland Univ, Inst Med Microbiol & Hyg, Homburg, Germany. (creator_code:org_t)

Related titles

  • In:Haematologica: Ferrata Storti Foundation108:12, s. 3347-33580390-60781592-8721

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view