Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies: A longitudinal study

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Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies : A longitudinal study

Lodin, Karin (författare): Karolinska Inst, Dept Med, Div Rheumatol, Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol R92, S-14186 Stockholm, Sweden.

Espinosa-Ortega, Fabricio (författare): Karolinska Inst, Dept Med, Div Rheumatol, Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.

Dastmalchi, Maryam (författare): Karolinska Inst, Dept Med, Div Rheumatol, Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.

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Vencovsky, Jiri (författare): Charles Univ Prague, Inst Rheumatol, Prague, Czech Republic.

Andersson, Helena (författare): Oslo Univ Hosp, Dept Rheumatol, Oslo, Norway.

Chinoy, Hector (författare): Univ Manchester, Manchester Univ NHS Fdn Trust, Natl Inst Hlth Res Manchester Biomed Res Ctr, Manchester, England.;Northern Care Alliance NHS Fdn Trust, Salford Royal Hosp, Manchester Acad Hlth Sci Ctr, Dept Rheumatol, Salford, England.;Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Ctr Musculoskeletal Res, Sch Biol Sci,Div Musculoskeletal & Dermatol Sci, Manchester, England.

Lilleker, James B. (författare): Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Ctr Musculoskeletal Res, Sch Biol Sci,Div Musculoskeletal & Dermatol Sci, Manchester, England.;Northern Care Alliance NHS Fdn Trust, Manchester Ctr Clin Neurosci, Neurophysiol Dept, Salford, England.

Shinjo, Samuel Katsuyuki (författare): Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo, SP, Brazil.

Maurer, Britta (författare): Bern Univ Hosp, Univ Bern, Dept Rheumatol & Immunol, Inselspital, CH-3010 Bern, Switzerland.

Griger, Zoltan (författare): Univ Debrecen, Fac Med, Div Clin Immunol, Debrecen, Hungary.

Ceribelli, Angela (författare): IRCCS Humanitas Res Hosp, Div Rheumatol & Clin Immunol, I-20089 Milan, Italy.;Humanitas Univ, Dept Biomed Sci, I-20072 Milan, Italy.

Torres-Ruiz, Jiram (författare): Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Immunol & Rheumatol, Mexico City, Mexico.

Vazquez -Del Mercado, M. (författare): Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Biol Mol & Genom, Inst Invest Reumatol & Sistema MÃºsculo Esqu, Guadalajara, Mexico.

Leonard, Dag, 1975- (författare): Uppsala universitet,Reumatologi

Alexanderson, Helene (författare): Karolinska Inst, Dept Med, Div Rheumatol, Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Occupat Therapy & Phys Therapy, Womens Hlth & Hlth Profess Theme, Stockholm, Sweden.

Lundberg, Ingrid E. (författare): Karolinska Inst, Dept Med, Div Rheumatol, Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.

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Karolinska Inst, Dept Med, Div Rheumatol, Solna, Stockholm, Sweden;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol R92, S-14186 Stockholm, Sweden. Karolinska Inst, Dept Med, Div Rheumatol, Solna, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Gastroenterol Dermatol & Rheumatol, Stockholm, Sweden. (creator_code:org_t)

Elsevier, 2024
2024
Engelska.
Ingår i: Seminars in Arthritis & Rheumatism. - : Elsevier. - 0049-0172 .- 1532-866X. ; 65

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AimTo explore if patient global assessment (PGA) is associated with inflammation over time and if associations are explained by other measures of disease activity and function in patients with idiopathic inflammatory myopathies (IIM).MethodsPGA and systemic inflammatory markers prospectively collected over five years were retrieved from the International MyoNet registry for 1200 patients with IIM. Associations between PGA, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and creatine kinase (CK) were analyzed using mixed models. Mediation analysis was used to test if the association between PGA and inflammatory markers during the first year of observation could be explained by measures of disease activity and function.ResultsPGA improved, and inflammatory markers decreased during the first year of observation. In the mixed models, high levels of inflammatory markers were associated with worse PGA in both men and women across time points during five years of observation. In men, but not in women, the association between elevated ESR, CRP and poorer PGA was explained by measures of function and disease activity. With a few exceptions, the association between improved PGA and reduced inflammatory markers was partially mediated by improvements in all measures of function and disease activity.ConclusionIncreased levels of systemic inflammation are associated with poorer PGA in patients with IIM. In addition to known benefits of lowered inflammation, these findings emphasize the need to reduce systemic inflammation to improve subjective health in patients with IIM. Furthermore, the results demonstrate the importance of incorporating PGA as an outcome measure in clinical practice and clinical trials.

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Av författaren/redakt...: Lodin, Karin; Espinosa-Ortega, ...; Dastmalchi, Mary ...; Vencovsky, Jiri; Andersson, Helen ...; Chinoy, Hector; visa fler...; Lilleker, James ...; Shinjo, Samuel K ...; Maurer, Britta; Griger, Zoltan; Ceribelli, Angel ...; Torres-Ruiz, Jir ...; Vazquez -Del Mer ...; Leonard, Dag, 19 ...; Alexanderson, He ...; Lundberg, Ingrid ...; visa färre...

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Patient global assessment and inflammatory markers in patients with idiopathic inflammatory myopathies : A longitudinal study

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