Strong Purifying Selection in Haploid Tissue-Specific Genes of Scots Pine Supports the Masking Theory

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Cervantes, SandraUniv Oulu, Dept Ecol & Genet, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland. (författare)

Strong Purifying Selection in Haploid Tissue-Specific Genes of Scots Pine Supports the Masking Theory

Artikel/kapitelEngelska2023

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Oxford University Press,2023
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LIBRIS-ID:oai:DiVA.org:uu-525893
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-525893URI
https://doi.org/10.1093/molbev/msad183DOI

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Språk:engelska
Sammanfattning på:engelska

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The masking theory states that genes expressed in a haploid stage will be under more efficient selection. In contrast, selection will be less efficient in genes expressed in a diploid stage, where the fitness effects of recessive deleterious or beneficial mutations can be hidden from selection in heterozygous form. This difference can influence several evolutionary processes such as the maintenance of genetic variation, adaptation rate, and genetic load. Masking theory expectations have been confirmed in single-cell haploid and diploid organisms. However, in multicellular organisms, such as plants, the effects of haploid selection are not clear-cut. In plants, the great majority of studies indicating haploid selection have been carried out using male haploid tissues in angiosperms. Hence, evidence in these systems is confounded with the effects of sexual selection and intraspecific competition. Evidence from other plant groups is scarce, and results show no support for the masking theory. Here, we have used a gymnosperm Scots pine megagametophyte, a maternally derived seed haploid tissue, and four diploid tissues to test the strength of purifying selection on a set of genes with tissue-specific expression. By using targeted resequencing data of those genes, we obtained estimates of genetic diversity, the site frequency spectrum of 0-fold and 4-fold sites, and inferred the distribution of fitness effects of new mutations in haploid and diploid tissue-specific genes. Our results show that purifying selection is stronger for tissue-specific genes expressed in the haploid megagametophyte tissue and that this signal of strong selection is not an artifact driven by high expression levels.

Ämnesord och genrebeteckningar

NATURVETENSKAP Biologi Evolutionsbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Evolutionary Biology hsv//eng
haploid selection
masking theory
purifying selection
gymnosperms
Pinus sylvestris
DFE

Biuppslag (personer, institutioner, konferenser, titlar ...)

Kesalähti, RobertUniv Oulu, Dept Ecol & Genet, Oulu, Finland. (författare)
Kumpula, Timo A.Univ Oulu, Bioctr Oulu, Oulu, Finland.;Univ Oulu, Res Unit Translat Med, Lab Canc Genet & Tumor Biol, Oulu, Finland. (författare)
Mattila, Tiina M.Uppsala universitet,Människans evolution(Swepub:uu)tiima649 (författare)
Helanterä, HeikkiUniv Oulu, Dept Ecol & Genet, Oulu, Finland. (författare)
Pyhäjärvi, TanjaUniv Helsinki, Dept Forest Sci, Helsinki, Finland. (författare)
Univ Oulu, Dept Ecol & Genet, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.Univ Oulu, Dept Ecol & Genet, Oulu, Finland. (creator_code:org_t)

Sammanhörande titlar

Ingår i:Molecular biology and evolution: Oxford University Press40:80737-40381537-1719

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Av författaren/redakt...: Cervantes, Sandr ...; Kesalähti, Rober ...; Kumpula, Timo A.; Mattila, Tiina M ...; Helanterä, Heikk ...; Pyhäjärvi, Tanja

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