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  • Jotanovic, JelenaUppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Clinical Pathology, Uppsala University Hospital, Uppsala, Sweden,Klinisk patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden. (author)

Transcriptome Analysis Reveals Distinct Patterns Between the Invasive and Noninvasive Pituitary Neuroendocrine Tumors

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • Oxford University Press,2024
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-525982
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-525982URI
  • https://doi.org/10.1210/jendso/bvae040DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-345163URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Correction in: Journal of the Endocrine Society, vol. 8, issue 6, article-id bvae068DOI: 10.1210/jendso/bvae068 
  • QC 20240408
  • Although most pituitary neuroendocrine tumors (PitNETs)/pituitary adenomas remain intrasellar, a significant proportion of tumors show parasellar invasive growth and 6% to 8% infiltrate the bone structures, thus affecting the prognosis. There is an unmet need to identify novel markers that can predict the parasellar growth of PitNETs. Furthermore, mechanisms that regulate bone invasiveness of PitNETs and factors related to tumor vascularization are largely unknown.We used genome-wide mRNA analysis in a cohort of 77 patients with PitNETs of different types to explore the differences in gene expression patterns between invasive and noninvasive tumors with respect to the parasellar growth and regarding the rare phenomenon of bone invasiveness. Additionally, we studied the genes correlated to the contrast enhancement quotient, a novel radiological parameter of tumor vascularization.Most of the genes differentially expressed related to the parasellar growth were genes involved in tumor invasiveness. Differentially expressed genes associated with bone invasiveness are involved in NF-κB pathway and antitumoral immune response. Lack of clear clustering regarding the parasellar and bone invasiveness may be explained by the influence of the cell lineage-related genes in this heterogeneous cohort of PitNETs.Our transcriptomics analysis revealed differences in the molecular fingerprints between invasive, including bone invasive, and noninvasive PitNETs, although without clear clustering. The contrast enhancement quotient emerged as a radiological parameter of tumor vascularization, correlating with several angiogenesis-related genes. Several of the top genes related to the PitNET invasiveness and vascularization have potential prognostic and therapeutic application requiring further research.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Abdellah, TebaniKTH,Systembiologi,Science for Life Laboratory, SciLifeLab,KNormandie Univ, Dept Metab Biochem, INSERM U1245, UNIROUEN,CHU Rouen, F-76000 Rouen, France.(Swepub:kth)u17jnmwg (author)
  • Hekmati, NedaUppsala universitet,Cancerimmunterapi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden.(Swepub:uu)nedhe862 (author)
  • Sivertsson, ÅsaKTH,Systembiologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u195d5b0 (author)
  • Lindskog, CeciliaUppsala universitet,Cancerprecisionsmedicin,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden.(Swepub:uu)cecli129 (author)
  • Uhlén, MathiasKTH,Systembiologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1dulvmw (author)
  • Gudjonsson, OlafurUppsala universitet,Neurokirurgi,Uppsala Univ, Dept Neurosci, S-75185 Uppsala, Sweden.(Swepub:uu)olafgudj (author)
  • Tsatsaris, ErikaUppsala universitet,Endokrinologi och mineralmetabolism,Uppsala Univ, Dept Med Sci, Endocrinol & Mineral Metab, S-75185 Uppsala, Sweden.(Swepub:uu)erits420 (author)
  • Edén Engström, BrittUppsala universitet,Endokrinologi och mineralmetabolism,Uppsala Univ, Dept Med Sci, Endocrinol & Mineral Metab, S-75185 Uppsala, Sweden.(Swepub:uu)brittee (author)
  • Wikström, Johan,Professor,1964-Uppsala universitet,Institutionen för kirurgiska vetenskaper,Neuroradiologi,Uppsala Univ, Dept Surg Sci, Neuroradiol, S-75185 Uppsala, Sweden.(Swepub:uu)jwi06759 (author)
  • Pontén, FredrikUppsala universitet,Cancerprecisionsmedicin,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden.(Swepub:uu)fredpont (author)
  • Casar-Borota, OliveraUppsala universitet,Institutionen för immunologi, genetik och patologi,Department of Clinical Pathology, Uppsala University Hospital, Uppsala, Sweden,Klinisk patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjolds V 20, S-75185 Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, S-75185 Uppsala, Sweden.(Swepub:uu)olica753 (author)
  • Uppsala universitetInstitutionen för immunologi, genetik och patologi (creator_code:org_t)

Related titles

  • In:Journal of the Endocrine Society: Oxford University Press8:52472-1972

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