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Mass Spectrometry P...
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Urbiola-Salvador, VictorUniv Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.
(författare)
Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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Sage Publications,2024
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-534881
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-534881URI
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https://doi.org/10.1177/11772719241257739DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Colorectal cancer (CRC) prognosis is determined by the disease stage with low survival rates for advanced stages. Current CRC screening programs are mainly using colonoscopy, limited by its invasiveness and high cost. Therefore, non-invasive, cost-effective, and accurate alternatives are urgently needed.Objective and design: This retrospective multi-center plasma proteomics study was performed to identify potential blood-based biomarkers in 36 CRC patients and 26 healthy volunteers by high-resolution mass spectrometry proteomics followed by the validation in an independent CRC cohort (60 CRC patients and 44 healthy subjects) of identified selected biomarkers.Results: Among the 322 identified plasma proteins, 37 were changed between CRC patients and healthy volunteers and were associated with the complement cascade, cholesterol metabolism, and SERPIN family members. Increased levels in CRC patients of the complement proteins C1QB, C4B, and C5 as well as pro-inflammatory proteins, lipopolysaccharide-binding protein (LBP) and serum amyloid A4, constitutive (SAA4) were revealed for first time. Importantly, increased level of C5 was verified in an independent validation CRC cohort. Increased C4B and C8A levels were correlated with cancer-associated inflammation and CRC progression, while cancer-associated inflammation was linked to the acute-phase reactant leucine-rich alpha-2-glycoprotein 1 (LRG1) and ceruloplasmin. Moreover, a 4-protein signature including C4B, C8A, apolipoprotein C2 (APO) C2, and immunoglobulin heavy constant gamma 2 was changed between early and late CRC stages.Conclusion: Our results suggest that C5 could be a potential biomarker for CRC diagnosis. Further validation studies will aid the application of these new potential biomarkers to improve CRC diagnosis and patient care.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Jablonska, AgnieszkaUniv Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.
(författare)
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Miroszewska, DominikaUniv Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.
(författare)
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Kamysz, WeronikaUniv Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.
(författare)
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Duzowska, KatarzynaUniv Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.
(författare)
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Drezek-Chyla, KingaMed Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.
(författare)
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Baber, RonnyUniv Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Univ Klinikum Leipzig, Leipzig, Saxony, Germany.;Univ Leipzig, Leipzig Med Biobank, Leipzig, Saxony, Germany.
(författare)
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Thieme, ReneUniv Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Saxony, Germany.
(författare)
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Gockel, InesUniv Hosp Leipzig, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Saxony, Germany.
(författare)
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Zdrenka, MarekProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Kuyavian Pomera, Poland.
(författare)
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Srutek, EwaProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Kuyavian Pomera, Poland.
(författare)
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Szylberg, LukaszProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Kuyavian Pomera, Poland.;Nicolaus Copernicus Univ Torun, Dept Obstet Gynaecol & Oncol, Coll Med Bydgoszcz, Bydgoszcz, Kuyavian Pomera, Poland.
(författare)
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Jankowski, MichalNicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Kuyavian Pomera, Poland.
(författare)
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Bala, DariuszNicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Kuyavian Pomera, Poland.
(författare)
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Zegarski, WojciechNicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Kuyavian Pomera, Poland.;Specialist Hosp Koscierzyna, Clin Gen & Oncol Surg, Koscierzyna, Pomeranian, Poland.
(författare)
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Nowikiewicz, TomaszNicolaus Copernicus Univ, Surg Oncol, Ludw Rydygiers Coll Med, Torun, Kuyavian Pomera, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Breast Canc & Reconstruct Surg, Bydgoszcz, Kuyavian Pomera, Poland.
(författare)
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Makarewicz, WojciechProf Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Breast Canc & Reconstruct Surg, Bydgoszcz, Kuyavian Pomera, Poland.
(författare)
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Adamczyk, AgnieszkaMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.
(författare)
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Ambicka, AleksandraMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.
(författare)
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Przewoznik, MarcinMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.
(författare)
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Harazin-Lechowska, AgnieszkaMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.
(författare)
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Rys, JanuszMaria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.
(författare)
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Macur, KatarzynaUniv Gdansk, Lab Mass Spectrometry, Core Facil Labs, Intercollegiate Fac Biotechnol, Gdansk, Pomeranian, Poland.
(författare)
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Czaplewska, PaulinaUniv Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Lab Mass Spectrometry, Core Facil Labs, Intercollegiate Fac Biotechnol, Gdansk, Pomeranian, Poland.
(författare)
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Filipowicz, NataliaMed Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.
(författare)
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Piotrowski, ArkadiuszMed Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.
(författare)
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Dumanski, Jan P.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin,Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.;Med Univ Gdansk, Dept Biol & Pharmaceut Bot, Gdansk, Pomeranian, Poland.(Swepub:uu)janduman
(författare)
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Chen, ZhiUniv Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Oulu, Fac Biochem & Mol Med, Oulu, Finland.
(författare)
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Univ Gdansk, Intercollegiate Fac Biotechnol, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.Univ Gdansk, Med Univ Gdansk, Brahama 58 St, PL-80307 Gdansk, Pomeranian, Poland.;Med Univ Gdansk, Med Lab 3P, Gdansk, Pomeranian, Poland.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biomarker Insights: Sage Publications191177-2719
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Urbiola-Salvador ...
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Jablonska, Agnie ...
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Miroszewska, Dom ...
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Kamysz, Weronika
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Duzowska, Katarz ...
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Drezek-Chyla, Ki ...
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visa fler...
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Baber, Ronny
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Thieme, Rene
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Gockel, Ines
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Zdrenka, Marek
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Srutek, Ewa
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Szylberg, Lukasz
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Jankowski, Micha ...
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Bala, Dariusz
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Zegarski, Wojcie ...
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Nowikiewicz, Tom ...
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Makarewicz, Wojc ...
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Adamczyk, Agnies ...
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Ambicka, Aleksan ...
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Przewoznik, Marc ...
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Harazin-Lechowsk ...
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Rys, Janusz
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Macur, Katarzyna
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Czaplewska, Paul ...
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Filipowicz, Nata ...
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Piotrowski, Arka ...
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Dumanski, Jan P.
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Chen, Zhi
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