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The Conceptual Definition of Sarcopenia : Delphi Consensus from the Global Leadership Initiative in Sarcopenia (GLIS)

Kirk, Ben (författare)
Univ Melbourne, Melbourne Med Sch, Dept Med, Western Hlth, Melbourne, Vic, Australia.;Univ Melbourne, Australian Inst Musculoskeletal Sci AIMSS, Melbourne, Vic, Australia.;Western Hlth, Melbourne, Vic, Australia.
Cawthon, Peggy M. (författare)
Calif Pacific Med Ctr, Res Inst, 550 16th St,Second Floor, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
Arai, Hidenori (författare)
Natl Ctr Geriatr & Gerontol, Obu, Aichi, Japan.
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Avila-Funes, Jose A. (författare)
Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Geriatr, Mexico City, Mexico.;Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, UMR 1219, Inserm, F-33000 Bordeaux, France.
Barazzoni, Rocco (författare)
Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
Bhasin, Shalender (författare)
Harvard Med Sch, Brigham & Womens Hosp, Boston Claude D Pepper Older Amer Independence Ct, Boston, MA USA.
Binder, Ellen F. (författare)
Washington Univ, Sch Med, Div Gen Med & Geriatr, St Louis, MO USA.
Bruyere, Olivier (författare)
Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Musculo S, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium.;Univ Liege, Dept Sport & Rehabil Sci, Liege, Belgium.
Cederholm, Tommy (författare)
Uppsala universitet,Klinisk nutrition och metabolism,Karolinska Univ Hosp, Theme Inflammat & Ageing, Stockholm, Sweden.
Chen, Liang-Kung (författare)
Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, Taipei, Taiwan.;Natl Yang Ming Chiao Tung Univ, Ctr Hlth Longev & Aging Sci, Taipei, Taiwan.
Cooper, Cyrus (författare)
Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, England.;Univ Oxford, Dept Epidemiol, Oxford, England.
Duque, Gustavo (författare)
McGill Univ, Bone Muscle & Gerosci Grp, Res Inst, Hlth Ctr, Montreal, PQ, Canada.;McGill Univ, Dr Joseph Kaufmann Chair Geriatr Med, Dept Med, Montreal, PQ, Canada.
Fielding, Roger A. (författare)
Tufts Univ, Jean Mayer US Dept Agr, Nutr Exercise Physiol & Sarcopenia Lab, Human Nutr Res Ctr Aging, Boston, MA USA.
Guralnik, Jack (författare)
Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD USA.
Kiel, Douglas P. (författare)
Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA.;Harvard Med Sch, Hinda & Arthur Marcus Inst Aging Res, Hebrew SeniorLife, Boston, MA USA.
Landi, Francesco (författare)
Fdn Policlin Univ Agostino Gemelli IRCCS, I-00168 Rome, Italy.
Reginster, Jean-Yves (författare)
WHO Collaborating Ctr Epidemiol Musculoskeletal H, Liege, Belgium.;King Saud Univ, Coll Sci, Chair Biomarkers Chron Dis, Riyadh, Saudi Arabia.
Sayer, Avan A. (författare)
Newcastle Univ, Newcastle Hosp, AGE Res Grp, NIHR Newcastle Biomed Res Ctr, Newcastle, England.;Newcastle Univ, Fac Med Sci, Newcastle, England.
Visser, Marjolein (författare)
Vrije Univ Amsterdam, Fac Sci, Dept Hlth Sci, Amsterdam, Netherlands.;Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
von Haehling, Stephan (författare)
Univ Med Gottingen UMG, Dept Cardiol & Pneumol, Gottingen, Germany.;German Ctr Cardiovasc Res DZHK, Partner Site Gottingen, Gottingen, Germany.
Woo, Jean (författare)
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.
Cruz-Jentoft, Alfonso J. (författare)
Hosp Univ Ramon y Cajal IRYCIS, Serv Geriatria, Madrid, Spain.
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Univ Melbourne, Melbourne Med Sch, Dept Med, Western Hlth, Melbourne, Vic, Australia;Univ Melbourne, Australian Inst Musculoskeletal Sci AIMSS, Melbourne, Vic, Australia.;Western Hlth, Melbourne, Vic, Australia. Calif Pacific Med Ctr, Res Inst, 550 16th St,Second Floor, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA. (creator_code:org_t)
Oxford University Press, 2024
2024
Engelska.
Ingår i: Age and Ageing. - : Oxford University Press. - 0002-0729 .- 1468-2834. ; 53:3
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Importance Sarcopenia, the age-related loss of muscle mass and strength/function, is an important clinical condition. However, no international consensus on the definition exists. Objective The Global Leadership Initiative in Sarcopenia (GLIS) aimed to address this by establishing the global conceptual definition of sarcopenia. Design The GLIS steering committee was formed in 2019-21 with representatives from all relevant scientific societies worldwide. During this time, the steering committee developed a set of statements on the topic and invited members from these societies to participate in a two-phase International Delphi Study. Between 2022 and 2023, participants ranked their agreement with a set of statements using an online survey tool (SurveyMonkey). Statements were categorised based on predefined thresholds: strong agreement (>80%), moderate agreement (70-80%) and low agreement (<70%). Statements with strong agreement were accepted, statements with low agreement were rejected and those with moderate agreement were reintroduced until consensus was reached. Results 107 participants (mean age: 54 +/- 12 years [1 missing age], 64% men) from 29 countries across 7 continents/regions completed the Delphi survey. Twenty statements were found to have a strong agreement. These included; 6 statements on 'general aspects of sarcopenia' (strongest agreement: the prevalence of sarcopenia increases with age (98.3%)), 3 statements on 'components of sarcopenia' (muscle mass (89.4%), muscle strength (93.1%) and muscle-specific strength (80.8%) should all be a part of the conceptual definition of sarcopenia)) and 11 statements on 'outcomes of sarcopenia' (strongest agreement: sarcopenia increases the risk of impaired physical performance (97.9%)). A key finding of the Delphi survey was that muscle mass, muscle strength and muscle-specific strength were all accepted as 'components of sarcopenia', whereas impaired physical performance was accepted as an 'outcome' rather than a 'component' of sarcopenia. Conclusion and relevance The GLIS has created the first global conceptual definition of sarcopenia, which will now serve to develop an operational definition for clinical and research settings.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)

Nyckelord

older people
conceptual
definitions
sarcopenia
GLIS

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