Search: id:"swepub:oai:DiVA.org:uu-526896" >
Lymphatic malformat...
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Petkova, MilenaUppsala universitet,Vaskulärbiologi
(author)
Lymphatic malformations : mechanistic insights and evolving therapeutic frontiers
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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American Society For Clinical Investigation,2024
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-526896
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-526896URI
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https://doi.org/10.1172/JCI172844DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The lymphatic vascular system is gaining recognition for its multifaceted role and broad pathological significance. Once perceived as a mere conduit for interstitial fluid and immune cell transport, recent research has unveiled its active involvement in critical physiological processes and common diseases, including inflammation, autoimmune diseases, and atherosclerosis. Consequently, abnormal development or functionality of lymphatic vessels can result in serious health complications. Here, we discuss lymphatic malformations (LMs), which are localized lesions that manifest as fluid -filled cysts or extensive infiltrative lymphatic vessel overgrowth, often associated with debilitating, even life -threatening, consequences. Genetic causes of LMs have been uncovered, and several promising drug -based therapies are currently under investigation and will be discussed.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Ferby, IngvarUppsala universitet,Vaskulärbiologi(Swepub:uu)ingfe628
(author)
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Mäkinen, TaijaUppsala universitet,Vaskulärbiologi,Wihuri Res Inst, Biomedicum Helsinki, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.(Swepub:uu)taima352
(author)
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Uppsala universitetVaskulärbiologi
(creator_code:org_t)
Related titles
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In:Journal of Clinical Investigation: American Society For Clinical Investigation134:60021-97381558-8238
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