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Sökning: id:"swepub:oai:DiVA.org:uu-527047" > The enigma of scler...

  • Vergouwen, Daphne P. C.Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands. (författare)

The enigma of sclera-specific autoimmunity in scleritis

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-527047
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-527047URI
  • https://doi.org/10.1016/j.jaut.2024.103178DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • van Beek, Adriaan A.Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands. (författare)
  • de Hoog, JoeriDept Ophthalmol, Amsterdam UMC, Amsterdam, Netherlands. (författare)
  • de Boer, Joke H.Dept Ophthalmol, UMC Utrecht, Utrecht, Netherlands. (författare)
  • Los, Leonoor I.Dept Ophthalmol, UMC Groningen, Groningen, Netherlands. (författare)
  • Gijs, MarliesUniv Eye Clin, Maastricht UMC, Maastricht, Netherlands. (författare)
  • Erckens, Roel J.Univ Eye Clin, Maastricht UMC, Maastricht, Netherlands. (författare)
  • Verdijk, Rob M.Univ Med Ctr Rotterdam, Dept Pathol, Erasmus MC, Rotterdam, Netherlands. (författare)
  • Haasnoot, Geert W.Leiden Univ Med Ctr, Eurotransplant Reference Lab, Leiden, Netherlands. (författare)
  • Roelen, Dave L.Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands. (författare)
  • Rothova, AnikiUniv Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands. (författare)
  • Rönnelid, JohanUppsala universitet,Vaskulärbiologi(Swepub:uu)joharonn (författare)
  • Berge, Josianne C. TenUniv Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands. (författare)
  • Schreurs, Marco W. J.Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands. (författare)
  • Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands.Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Autoimmunity: Elsevier1440896-84111095-9157

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