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The enigma of scler...
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Vergouwen, Daphne P. C.Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands.
(författare)
The enigma of sclera-specific autoimmunity in scleritis
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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Elsevier,2024
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-527047
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-527047URI
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https://doi.org/10.1016/j.jaut.2024.103178DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Scleritis is a severe and painful ophthalmic disorder, in which a pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies in a large cohort of patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 patients with non-infectious scleritis in a multicenter cohort study in the Netherlands. In addition, healthy (n = 39) and uveitis controls (n = 48) were included. Serum samples were tested for anti-native human type II collagen antibodies using a validated enzyme-linked immunosorbent assay (ELISA). Further, sclera-specific antibodies were determined using indirect immunofluorescence (IIF) on primate retinal/scleral cryosections. Lastly, human leukocyte antigen (HLA) typing was performed in 111 patients with scleritis. Anti-type II collagen antibodies were found in 13% of scleritis patients, in 10% of healthy controls and in 11% of uveitis controls (p = 0.91). A specific reaction to scleral nerve tissue on IIF was observed in 33% of patients with scleritis, which was higher than in healthy controls (11%; p = 0.01), but similar to uveitis controls (25%; p = 0.36). Reactivity to the scleral nerve tissue was significantly associated with earlier onset of scleritis (48 versus 56 years; p < 0.001), bilateral involvement (65% versus 42%; p = 0.01), and less frequent development of scleral necrosis (5% versus 22%; p = 0.02). HLA-B27 was found to be twice as prevalent in patients with scleritis (15.3%) compared to a healthy population (7.2%). In conclusion, scleral nerve autoantibody reactivity was more common in scleritis and uveitis patients in contrast to healthy controls. Further research is needed to characterize these scleral-nerve directed antibodies and assess their clinical value.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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van Beek, Adriaan A.Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands.
(författare)
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de Hoog, JoeriDept Ophthalmol, Amsterdam UMC, Amsterdam, Netherlands.
(författare)
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de Boer, Joke H.Dept Ophthalmol, UMC Utrecht, Utrecht, Netherlands.
(författare)
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Los, Leonoor I.Dept Ophthalmol, UMC Groningen, Groningen, Netherlands.
(författare)
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Gijs, MarliesUniv Eye Clin, Maastricht UMC, Maastricht, Netherlands.
(författare)
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Erckens, Roel J.Univ Eye Clin, Maastricht UMC, Maastricht, Netherlands.
(författare)
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Verdijk, Rob M.Univ Med Ctr Rotterdam, Dept Pathol, Erasmus MC, Rotterdam, Netherlands.
(författare)
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Haasnoot, Geert W.Leiden Univ Med Ctr, Eurotransplant Reference Lab, Leiden, Netherlands.
(författare)
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Roelen, Dave L.Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands.
(författare)
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Rothova, AnikiUniv Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.
(författare)
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Rönnelid, JohanUppsala universitet,Vaskulärbiologi(Swepub:uu)joharonn
(författare)
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Berge, Josianne C. TenUniv Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.
(författare)
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Schreurs, Marco W. J.Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.
(författare)
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Univ Med Ctr Rotterdam, Dept Ophthalmol, Erasmus MC, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.;Dept ophthalmol, Erasmus MC, Dr Molewaterplein 40, NL-3015GD Rotterdam, Netherlands.Leiden Univ Med Ctr, Dept Immunol, HLA Lab, Leiden, Netherlands.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Autoimmunity: Elsevier1440896-84111095-9157
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Vergouwen, Daphn ...
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van Beek, Adriaa ...
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de Hoog, Joeri
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de Boer, Joke H.
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Los, Leonoor I.
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Gijs, Marlies
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Erckens, Roel J.
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Verdijk, Rob M.
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Haasnoot, Geert ...
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Roelen, Dave L.
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Rothova, Aniki
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Rönnelid, Johan
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Berge, Josianne ...
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Schreurs, Marco ...
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