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Living Donor Liver ...
Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria
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- Ivanics, Tommy (författare)
- Uppsala universitet,Gastrointestinalkirurgi,Univ Hlth Network, Dept Surg, Multiorgan Transplant Program, Toronto, ON, Canada.;Henry Ford Hosp, Dept Orthoped Surg, Detroit, MI USA.
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- Claasen, Marco P. A. W. (författare)
- Univ Hlth Network, Dept Surg, Multiorgan Transplant Program, Toronto, ON, Canada.;Erasmus MC, Univ Med Ctr Rotterdam, Dept Surg, Div HPB & Transplant Surg,Transplant Inst, Rotterdam, Netherlands.
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- Samstein, Benjamin (författare)
- Weill Cornell Med, Dept Surg, Div Liver Transplantat & Hepatobiliary Surg, New York, NY USA.
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- Emond, Jean C. (författare)
- Columbia Univ, New York Presbyterian Hosp, Ctr Liver Dis & Transplantat, Div Digest & Liver Dis,Med Ctr, New York, NY USA.
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- Fox, Alyson N. (författare)
- Columbia Univ, New York Presbyterian Hosp, Ctr Liver Dis & Transplantat, Div Digest & Liver Dis,Med Ctr, New York, NY USA.
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- Pomfret, Elizabeth (författare)
- Univ Colorado, Sch Med, Dept Surg, Div Transplant Surg, Aurora, CO USA.
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- Pomposelli, James (författare)
- Univ Colorado, Sch Med, Dept Surg, Div Transplant Surg, Aurora, CO USA.
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- Tabrizian, Parissa (författare)
- Icahn Sch Med Mt Sinai, Recanati Miller Transplantat Inst, Dept Surg, Div Abdominal Transplantat, New York, NY USA.
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- Florman, Sander S. (författare)
- Icahn Sch Med Mt Sinai, Recanati Miller Transplantat Inst, Dept Surg, Div Abdominal Transplantat, New York, NY USA.
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- Mehta, Neil (författare)
- Univ Calif San Francisco, Dept Med, Div Gastroenterol, San Francisco, CA USA.
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- Roberts, John P. (författare)
- Univ Calif San Francisco, Dept Surg, San Francisco, CA USA.
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- Emamaullee, Juliet A. (författare)
- Univ Southern Calif, Dept Surg, Los Angeles, CA USA.
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- Genyk, Yuri (författare)
- Univ Southern Calif, Dept Surg, Los Angeles, CA USA.
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- Hernandez-Alejandro, Roberto (författare)
- Univ Rochester, Dept Surg, Div Transplantat Hepatobiliary Surg, Rochester, NY USA.
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- Tomiyama, Koji (författare)
- Univ Rochester, Dept Surg, Div Transplantat Hepatobiliary Surg, Rochester, NY USA.
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- Sasaki, Kazunari (författare)
- Stanford Hosp & Clin, Dept Surg Abdominal Transplantat, Palo Alto, CA USA.
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- Hashimoto, Koji (författare)
- Cleveland Clin, Digest Dis & Surg Inst, Dept Gen Surg, Cleveland, OH USA.
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- Nagai, Shunji (författare)
- Henry Ford Hosp, Dept Surg, Div Transplant & Hepatobiliary Surg, Detroit, MI USA.
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- Abouljoud, Marwan (författare)
- Henry Ford Hosp, Dept Surg, Div Transplant & Hepatobiliary Surg, Detroit, MI USA.
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- Olthoff, Kim M. (författare)
- Univ Penn, Perelman Sch Med, Dept Surg, Philadelphia, PA USA.
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- Hoteit, Maarouf A. (författare)
- Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA USA.
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- Heimbach, Julie (författare)
- Mayo Clin, Dept Surg, Div Transplantat Surg, Rochester, MN USA.
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- Taner, Timucin (författare)
- Mayo Clin, Dept Surg, Div Transplantat Surg, Rochester, MN USA.
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- Liapakis, AnnMarie H. (författare)
- NYU Langone Hlth, Dept Med, New York, NY USA.
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- Mulligan, David C. (författare)
- Yale Sch Med, Dept Surg, New Haven, CT USA.
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- Sapisochin, Gonzalo (författare)
- Univ Hlth Network, Dept Surg, Multiorgan Transplant Program, Toronto, ON, Canada.
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- Halazun, Karim J. (författare)
- NYU Langone Hlth, NYU Langone Transplant Inst, New York, NY 10016 USA.
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(creator_code:org_t)
- Wolters Kluwer, 2024
- 2024
- Engelska.
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Ingår i: Annals of Surgery. - : Wolters Kluwer. - 0003-4932 .- 1528-1140. ; 279:1, s. 104-111
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective:To evaluate long-term oncologic outcomes of patients post-living donor liver transplantation (LDLT) within and outside standard transplantation selection criteria and the added value of the incorporation of the New York-California (NYCA) score.Background:LDLT offers an opportunity to decrease the liver transplantation waitlist, reduce waitlist mortality, and expand selection criteria for patients with hepatocellular carcinoma (HCC).Methods:Primary adult LDLT recipients between October 1999 and August 2019 were identified from a multicenter cohort of 12 North American centers. Posttransplantation and recurrence-free survival were evaluated using the Kaplan-Meier method.Results:Three hundred sixty LDLTs were identified. Patients within Milan criteria (MC) at transplantation had a 1, 5, and 10-year posttransplantation survival of 90.9%, 78.5%, and 64.1% versus outside MC 90.4%, 68.6%, and 57.7% (P = 0.20), respectively. For patients within the University of California San Francisco (UCSF) criteria, respective posttransplantation survival was 90.6%, 77.8%, and 65.0%, versus outside UCSF 92.1%, 63.8%, and 45.8% (P = 0.08). Fifty-three (83%) patients classified as outside MC at transplantation would have been classified as either low or acceptable risk with the NYCA score. These patients had a 5-year overall survival of 72.2%. Similarly, 28(80%) patients classified as outside UCSF at transplantation would have been classified as a low or acceptable risk with a 5-year overall survival of 65.3%.Conclusions:Long-term survival is excellent for patients with HCC undergoing LDLT within and outside selection criteria, exceeding the minimum recommended 5-year rate of 60% proposed by consensus guidelines. The NYCA categorization offers insight into identifying a substantial proportion of patients with HCC outside the MC and the UCSF criteria who still achieve similar post-LDLT outcomes as patients within the criteria.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- hepatocellular carcinoma
- HCC
- liver transplantation
- living donor liver transplantation
- LDLT
- multicenter
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Till lärosätets databas
- Av författaren/redakt...
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Ivanics, Tommy
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Claasen, Marco P ...
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Samstein, Benjam ...
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Emond, Jean C.
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Fox, Alyson N.
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Pomfret, Elizabe ...
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visa fler...
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Pomposelli, Jame ...
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Tabrizian, Paris ...
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Florman, Sander ...
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Mehta, Neil
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Roberts, John P.
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Emamaullee, Juli ...
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Genyk, Yuri
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Hernandez-Alejan ...
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Tomiyama, Koji
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Sasaki, Kazunari
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Hashimoto, Koji
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Nagai, Shunji
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Abouljoud, Marwa ...
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Olthoff, Kim M.
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Hoteit, Maarouf ...
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Heimbach, Julie
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Taner, Timucin
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Liapakis, AnnMar ...
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Mulligan, David ...
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Sapisochin, Gonz ...
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Halazun, Karim J ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Annals of Surger ...
- Av lärosätet
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Uppsala universitet