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Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

Teuscher, Alina C. (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland.
Statzer, Cyril (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland.
Goyala, Anita (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland.
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Domenig, Seraina A. (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland.
Schoen, Ingmar (författare)
Royal Coll Surgeons Ireland, Irish Ctr Vasc Biol, Sch Pharm & Biomol Sci, Dublin, Ireland.;Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Appl Mechanobiol, Zurich, Switzerland.
Hess, Max (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland.
Hofer, Alexander M. (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland.
Fossati, Andrea (författare)
Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Zurich, Switzerland.;Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA.
Vogel, Viola (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Appl Mechanobiol, Zurich, Switzerland.
Göksel, Orcun (författare)
Uppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen Vi3,Swiss Fed Inst Technol, Dept Informat Technol & Elect Engn, Zurich, Switzerland.
Aebersold, Ruedi (författare)
Swiss Fed Inst Technol, Inst Mol Syst Biol, Dept Biol, Zurich, Switzerland.
Ewald, Collin Y. (författare)
Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland.
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Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Extracellular Matrix Regenerat, CH-8603 Schwerzenbach, Switzerland Royal Coll Surgeons Ireland, Irish Ctr Vasc Biol, Sch Pharm & Biomol Sci, Dublin, Ireland.;Swiss Fed Inst Technol, Inst Translat Med, Dept Hlth Sci & Technol, Lab Appl Mechanobiol, Zurich, Switzerland. (creator_code:org_t)
Springer Nature, 2024
2024
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during aging in C. elegans revealing three distinct collagen dynamics. Longevity interventions slow age-related collagen stiffening and prolong the expression of collagens that are turned over. These prolonged collagen dynamics are mediated by a mechanical feedback loop of hemidesmosome-containing structures that span from the exoskeletal ECM through the hypodermis, basement membrane ECM, to the muscles, coupling mechanical forces to adjust ECM gene expression and longevity via the transcriptional co-activator YAP-1 across tissues. Our results provide in-vivo evidence that coordinated ECM remodeling through mechanotransduction is required and sufficient to promote longevity, offering potential avenues for interventions targeting ECM dynamics.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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