Studies in children with obesity in two European treatment centres show a high prevalence of impaired glucose metabolism in the Swedish cohort

Ciba, IrisUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden. (author)

Aim: To investigate the prevalence and possible risk factors for the development of impaired glucose metabolism in children and adolescents with obesity.Methods: This was a cross-sectional retrospective cohort study, including 634 patients with obesity and 98 normal weight controls aged 4-18 years from the Beta-cell function in Juvenile Diabetes and Obesity (Beta-JUDO) cohort, a dual-centre study at Uppsala University Hospital (Sweden) and Paracelsus Medical University Hospital (Salzburg, Austria) conducted between 2012 and 2021. A longitudinal subgroup analysis, including 188 of these subjects was performed. Impaired glucose metabolism was diagnosed by oral glucose tolerance tests according to American Diabetes Association criteria.Results: The prevalence of impaired glucose metabolism was 72% in Uppsala patients, 24% in Salzburg patients, 30% in Uppsala controls and 13% in Salzburg controls. The prevalence was lower at the follow-up visits compared with baseline both in Uppsala and Salzburg patients. A family history of type 2 diabetes showed the strongest association with impaired glucose metabolism at the follow-up visits besides belonging to the Uppsala cohort.Conclusion: The prevalence of impaired glucose metabolism was extraordinarily high in Swedish children and adolescents with obesity, but decreased during the follow-up period.

Dahlbom, MarieUppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.(Swepub:uu)marda124 (author)
Manell, HannesUppsala universitet,Institutionen för medicinsk cellbiologi,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.(Swepub:uu)hanoh982 (author)
Mörwald, KatharinaParacelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria. (author)
Roomp, KirstenUniv Luxembourg, Luxembourg Ctr Syst Biomed, Belvaux, Luxembourg. (author)
Weghuber, DanielParacelsus Med Univ, Dept Pediat, Salzburg, Austria.;Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria. (author)
Bergsten, PeterUppsala universitet,Institutionen för medicinsk cellbiologi,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.(Swepub:uu)peteberg (author)
Forslund, Anders,1961-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Uppsala Univ, Childrens Hosp, Uppsala, Sweden.(Swepub:uu)andeforsl (author)
Uppsala universitetPediatrisk inflammations- och metabolismforskning samt barnhälsa (creator_code:org_t)

By the author/editor: Ciba, Iris; Dahlbom, Marie; Manell, Hannes; Mörwald, Kathari ...; Roomp, Kirsten; Weghuber, Daniel; show more...; Bergsten, Peter; Forslund, Anders ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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