SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Sternby Eilard Malin)
 

Sökning: WFRF:(Sternby Eilard Malin) > Importance of resec...

  • Ostrand, EmilSkane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden. (författare)

Importance of resection margin after resection of colorectal liver metastases in the era of modern chemotherapy : population-based cohort study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Oxford University Press,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-528222
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-528222URI
  • https://doi.org/10.1093/bjsopen/zrae035DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-203564URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Erik och Angelica Sparres forskningsstiftelse (EO)
  • Background Resection margin has been associated with overall survival following liver resection for colorectal liver metastasis. The aim of this study was to examine how resection margins of 0.0 mm, 0.1-0.9 mm and >= 1 mm influence overall survival in patients resected for colorectal liver metastasis in a time of modern perioperative chemotherapy and surgery. Methods Using data from the national registries Swedish Colorectal Cancer Registry and Swedish National Quality Registry for Liver, Bile Duct and Gallbladder Cancer, patients that had liver resections for colorectal liver metastasis between 2009 and 2013 were included. In patients with a narrow or unknown surgical margin the original pathological reports were re-reviewed. Factors influencing overall survival were analysed using a Cox proportional hazard model. Results A total of 754 patients had a known margin status, of which 133 (17.6%) patients had a resection margin <1 mm. The overall survival in patients with a margin of 0 mm or 0.1-0.9 mm was 42 (95% c.i. 31 to 53) and 48 (95% c.i. 35 to 62) months respectively, compared with 75 (95% c.i. 65 to 85) for patients with >= 1 mm margin, P < 0.001. Margins of 0 mm or 0.1-0.9 mm were associated with poor overall survival in the multivariable analysis, HR 1.413 (95% c.i. 1.030 to 1.939), P = 0.032, and 1.399 (95% c.i. 1.025 to 1.910), P = 0.034, respectively. Conclusions Despite modern chemotherapy the resection margin is still an important factor for the survival of patients resected for colorectal liver metastasis, and a margin of >= 1 mm is needed to achieve the best possible outcome.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Rystedt, JennySkane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden. (författare)
  • Engstrand, JennieKarolinska Univ Hosp, Div Surg, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden. (författare)
  • Frühling, PetterUppsala universitet,Institutionen för kirurgiska vetenskaper,Akad Univ Hosp, Sweden; Uppsala Univ, Sweden,Akad Univ Hosp, Dept Surg, Uppsala, Sweden.(Swepub:uu)petfr508 (författare)
  • Hemmingsson, OskarUmeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden. (författare)
  • Sandström, PerLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Linköping Univ Hosp, Dept Surg, Linköping, Sweden.;Linköping Univ, Dept Clin & Expt Med Sci, Linköping, Sweden.(Swepub:liu)persa07 (författare)
  • Eilard, Malin SternbySahlgrens Univ Hosp, Dept Transplantat & Liver Surg, Gothenburg, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Dept Clin Sci, Gothenburg, Sweden. (författare)
  • Tingstedt, BobbySkane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden. (författare)
  • Buchwald, PamelaSkane Univ Hosp, Dept Surg, Malmö, Sweden.;Lund Univ, Dept Clin Sci Malmö, Lund, Sweden. (författare)
  • Skane Univ Hosp, Dept Surg, SE-22185 Lund, Sweden.;Lund Univ, Dept Clin Sci Lund, Lund, Sweden.Karolinska Univ Hosp, Div Surg, Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BJS Open: Oxford University Press8:32474-9842

Internetlänk

Hitta via bibliotek

  • BJS Open (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy