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Letermovir prophyla...
Letermovir prophylaxis for cytomegalovirus reactivation in allogeneic hematopoietic cell transplant recipients : Single center Canadian data
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- Pang, Ian (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Chen, Peggy (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Trinh, Gertrude V. (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Remberger, Mats, Professor, 1955- (författare)
- Uppsala universitet,Hematologi,Uppsala Univ Hosp, KFUE, Uppsala, Sweden.
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- Novitzky-Basso, Igor (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Gerbitz, Armin (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Kim, Dennis D. (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Kumar, Rajat (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Lam, Wilson (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Law, Arjun D. (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Lipton, Jeffrey H. (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Viswabandya, Auro (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Pasic, Ivan (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Mattsson, Jonas (författare)
- Karolinska Institutet,Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.
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- Michelis, Fotios V. (författare)
- Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada.;Princess Margaret Canc Ctr, Div Med Oncol & Hematol, 610 Univ Ave, Toronto, ON M5G 2M9, Canada.
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Princess Margaret Canc Ctr, Hans Messner Allogene Transplant Program, Toronto, ON, Canada Hematologi (creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: European Journal of Haematology. - : John Wiley & Sons. - 0902-4441 .- 1600-0609. ; 112:2, s. 301-309
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Cytomegalovirus (CMV) is associated with morbidity and mortality following allogeneic hematopoietic cell transplantation (alloHCT). Letermovir is a novel antiviral agent that prevents CMV reactivation in alloHCT patients, with limited data regarding influence on post-alloHCT outcomes.Methods: We retrospectively examined 273 alloHCT recipients, 158 in the non-letermovir cohort (NLC), and 115 in the cohort using letermovir prophylaxis (LC). Patients that received letermovir were CMV-seropositive and met criteria for high risk of CMV reactivation.Results: Median start of letermovir was 21 days post-alloHCT, median duration of prophylaxis was 86 days. Letermovir prophylaxis demonstrated a statistically significant reduction in first CMV reactivation (at 200 days post 63.9% in the NLC vs. 35.7% in the LC; p < .001). On univariate analysis at 1 year, overall survival (OS) for NLC was 79.6% and 79.5% for LC (p = .54). Non relapse mortality (NRM) at 1 year for NLC was 12% and 12.3% for LC (p = .69). Cumulative incidence of relapse (CIR) at 1 year was 13.9% for NLC versus 17.1 for the LC (p = .27). On multivariable analysis, there was no significant difference between the two cohorts for OS, NRM, and CIR.Conclusions: Letermovir prophylaxis started at day +21 post-alloHCT reduced CMV reactivation, with no impact on posttransplant outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- allogeneic stem cell transplantation
- cytomegalovirus
- letermovir
- outcomes
- prophylaxis
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Till lärosätets databas
- Av författaren/redakt...
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Pang, Ian
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Chen, Peggy
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Trinh, Gertrude ...
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Remberger, Mats, ...
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Novitzky-Basso, ...
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Gerbitz, Armin
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Kim, Dennis D.
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Kumar, Rajat
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Lam, Wilson
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Law, Arjun D.
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Lipton, Jeffrey ...
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Viswabandya, Aur ...
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Pasic, Ivan
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Mattsson, Jonas
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Michelis, Fotios ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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European Journal ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet