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  • Amin, KawaUppsala universitet,Institutionen för medicinsk cellbiologi (author)

Inflammation and structural changes in the airways of patients with atopicand nonatopic asthma : BHR group

  • Article/chapterEnglish2000

Publisher, publication year, extent ...

  • 2000
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-52890
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-52890URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The aim of the present study was to compare the cellular pattern and structural changes in the airway walls of atopic and nonatopic patients with asthma. Bronchial biopsy specimens were obtained from 13 atopic subjects with asthma, nine nonatopic patients with asthma, and seven healthy control subjects and investigated using immunohistochemical methods. The number of eosinophils increased in both asthma groups, but significantly more in the atopic group. The number of mast cells increased similarly in the two asthma groups, whereas the number of neutrophils increased only in the nonatopic asthma group. The number of T-lymphocytes (CD3-, CD4-, CD8-, CD-25-positive cells) was higher in patients with atopic asthma compared with nonatopic asthma. Interleukin-4 (IL-4) and IL-5-positive cells were more frequently found in the atopic asthma group, whereas cells staining for IL-8 were more frequent in the nonatopic group. The degree of epithelial damage was significantly higher in the atopic asthma group compared with the control subjects and the nonatopic asthmatics. The tenascin and laminin layer was significantly thicker in the atopic group compared with the group of nonatopic asthmatics. In the atopic group, there was a significant negative correlation between epithelial integrity (defined as the relative length of intact epithelium) and the eosinophil count and also between the number of CD25-positive cells and epithelial integrity. The number of mast cells correlated positively with the thickness of tenascin- and laminin-positive layers. In conclusion, we provide evidence of different patterns of involvement of inflammatory cells in atopic and nonatopic patients with asthma. There were also structural differences in the bronchial mucous membrane between atopic asthma and nonatopic asthma. This suggests that there are differences in the extent of the immunopathologic response of these clinically distinct forms of asthma.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lúdvíksdóttir, DóraUppsala universitet,Institutionen för medicinska vetenskaper,Respiratory Medicine and Allergology (author)
  • Janson, ChristerUppsala universitet,Institutionen för medicinska vetenskaper,Respiratory Medicine and Allergology (author)
  • Nettelbladh, OttoUppsala universitet,Institutionen för medicinska vetenskaper,Respiratory Medicine and Allergology (author)
  • Björnsson, EythórUppsala universitet,Institutionen för medicinska vetenskaper,Respiratory Medicine and Allergology (author)
  • Roomans, Godfried M.Uppsala universitet,Institutionen för medicinsk cellbiologi (author)
  • Boman, GunnarUppsala universitet,Institutionen för medicinska vetenskaper,Respiratory Medicine and Allergology (author)
  • Sevéus, LahjaUppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Venge, PerUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)pervenge (author)
  • Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)

Related titles

  • In:American Journal of Respiratory and Critical Care Medicine162:6, s. 2295-23011073-449X1535-4970

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