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New approach method...
New approach methods to assess developmental and adult neurotoxicity for regulatory use : a PARC work package 5 project
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- Tal, Tamara (author)
- UFZ Helmholtz Ctr Environm Res, Chem Environm Res Sect, Leipzig, Germany.;Univ Leipzig, Med Fac, Leipzig, Germany.
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- Myhre, Oddvar (author)
- Norwegian Inst Publ Hlth NIPH, Dept Chem Toxicol, Oslo, Norway.
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- Fritsche, Ellen (author)
- IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany.;DNTOX GmbH, Dusseldorf, Germany.;Univ Basel, Swiss Ctr Appl Human Toxicol, Basel, Switzerland.
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- Rüegg, Joëlle (author)
- Uppsala universitet,Fysiologi och miljötoxikologi
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- Craenen, Kai (author)
- European Chem Agcy ECHA, Helsinki, Finland.
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- Aiello-Holden, Kiara (author)
- German Fed Inst Risk Assessment BfR, Berlin, Germany.
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- Agrillo, Caroline (author)
- Uppsala universitet,Fysiologi och miljötoxikologi
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- Babin, Patrick J. (author)
- Univ Bordeaux, Inst Natl St & Rech Med INSERM, Malad Rares Genet & Metab MRGM, Pessac, France.
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- Escher, Beate I. (author)
- UFZ Helmholtz Ctr Environm Res, Chem Environm Res Sect, Leipzig, Germany.
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- Dirven, Hubert (author)
- Norwegian Inst Publ Hlth NIPH, Dept Chem Toxicol, Oslo, Norway.
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- Hellsten, Kati (author)
- European Chem Agcy ECHA, Helsinki, Finland.
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- Dolva, Kristine (author)
- Univ Oslo, Dept Pharm, Sect Pharmacol & Pharmaceut Biosci, Oslo, Norway.
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- Hessel, Ellen (author)
- Dutch Nation Inst Publ Hlth & Environm RIVM, Ctr Hlth Protect, Bilthoven, Netherlands.
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- Heusinkveld, Harm J. (author)
- Dutch Nation Inst Publ Hlth & Environm RIVM, Ctr Hlth Protect, Bilthoven, Netherlands.
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- Hadzhiev, Yavor (author)
- Univ Birmingham, Ctr Environm Res & Justice, Birmingham, England.
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- Hurem, Selma (author)
- Norwegian Univ Life Sci NMBU, Fac Vet Med, As, Norway.
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- Jagiello, Karolina (author)
- Univ Gdansk, Lab Environm Chemoinformat, Gdansk, Poland.
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- Judzinska, Beata (author)
- Univ Gdansk, Lab Environm Chemoinformat, Gdansk, Poland.
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- Klüver, Nils (author)
- UFZ Helmholtz Ctr Environm Res, Chem Environm Res Sect, Leipzig, Germany.
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- Knoll-Gellida, Anja (author)
- Univ Bordeaux, Inst Natl St & Rech Med INSERM, Malad Rares Genet & Metab MRGM, Pessac, France.
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- Kühne, Britta A. (author)
- Univ Vet Med Hannover, Inst Food Qual & Food Safety, Hannover, Germany.
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- Leist, Marcel (author)
- Univ Konstanz, Vitro Toxicol & Biomed CAAT Europe, Constance, Germany.
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- Lislien, Malene (author)
- Norwegian Inst Publ Hlth NIPH, Dept Chem Toxicol, Oslo, Norway.
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- Lyche, Jan L. (author)
- Norwegian Univ Life Sci NMBU, Fac Vet Med, As, Norway.
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- Müller, Ferenc (author)
- Univ Birmingham, Ctr Environm Res & Justice, Birmingham, England.
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- Colbourne, John K. (author)
- Univ Birmingham, Ctr Environm Res & Justice, Birmingham, England.
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- Neuhaus, Winfried (author)
- AIT Austrian Inst Technol GmbH, Ctr Hlth & Bioresources, Competence Unit Mol Diagnost, Vienna, Austria.;Danube Private Univ, Fac Dent & Med, Dept Med, Krems, Austria.
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- Pallocca, Giorgia (author)
- Univ Konstanz, Vitro Toxicol & Biomed CAAT Europe, Constance, Germany.
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- Seeger, Bettina (author)
- Univ Vet Med Hannover, Inst Food Qual & Food Safety, Hannover, Germany.
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- Scharkin, Ilka (author)
- IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany.
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- Scholz, Stefan (author)
- UFZ Helmholtz Ctr Environm Res, Chem Environm Res Sect, Leipzig, Germany.
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- Spjuth, Ola, Professor, 1977- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab
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- Torres-Ruiz, Monica (author)
- Inst Salud Carlos III ISCIII, Ctr Nacl San Ambiental CNSA, Environm Toxicol Unit, Majadahonda, Spain.
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- Bartmann, Kristina (author)
- IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany.;DNTOX GmbH, Dusseldorf, Germany.
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UFZ Helmholtz Ctr Environm Res, Chem Environm Res Sect, Leipzig, Germany;Univ Leipzig, Med Fac, Leipzig, Germany. Norwegian Inst Publ Hlth NIPH, Dept Chem Toxicol, Oslo, Norway. (creator_code:org_t)
- Frontiers Media S.A. 2024
- 2024
- English.
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In: Frontiers in Toxicology. - : Frontiers Media S.A.. - 2673-3080. ; 6
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While the public expects chemicals and products to be safe for the developing and mature nervous systems, considerable numbers of chemicals in commerce have not, or only to a limited extent, been assessed for their potential to cause neurotoxicity. As such, there is a societal push toward the replacement of animal models with in vitro or alternative methods. New approach methods (NAMs) can contribute to the regulatory knowledge base, increase chemical safety, and modernize chemical hazard and risk assessment. Provided they reach an acceptable level of regulatory relevance and reliability, NAMs may be considered as replacements for specific in vivo studies. The European Partnership for the Assessment of Risks from Chemicals (PARC) addresses challenges to the development and implementation of NAMs in chemical risk assessment. In collaboration with regulatory agencies, Project 5.2.1e (Neurotoxicity) aims to develop and evaluate NAMs for developmental neurotoxicity (DNT) and adult neurotoxicity (ANT) and to understand the applicability domain of specific NAMs for the detection of endocrine disruption and epigenetic perturbation. To speed up assay time and reduce costs, we identify early indicators of later-onset effects. Ultimately, we will assemble second-generation developmental neurotoxicity and first-generation adult neurotoxicity test batteries, both of which aim to provide regulatory hazard and risk assessors and industry stakeholders with robust, speedy, lower-cost, and informative next-generation hazard and risk assessment tools.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- new approach method (NAM)
- developmental neurotoxicity (DNT)
- adult neurotoxicity (ANT)
- DNT-IVB
- zebrafish
- applicability domain
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Tal, Tamara
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Myhre, Oddvar
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Fritsche, Ellen
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Rüegg, Joëlle
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Craenen, Kai
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Aiello-Holden, K ...
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show more...
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Agrillo, Carolin ...
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Babin, Patrick J ...
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Escher, Beate I.
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Dirven, Hubert
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Hellsten, Kati
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Dolva, Kristine
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Hessel, Ellen
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Heusinkveld, Har ...
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Hadzhiev, Yavor
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Hurem, Selma
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Jagiello, Karoli ...
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Judzinska, Beata
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Klüver, Nils
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Knoll-Gellida, A ...
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Kühne, Britta A.
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Leist, Marcel
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Lislien, Malene
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Lyche, Jan L.
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Müller, Ferenc
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Colbourne, John ...
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Neuhaus, Winfrie ...
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Pallocca, Giorgi ...
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Seeger, Bettina
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Scharkin, Ilka
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Scholz, Stefan
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Spjuth, Ola, Pro ...
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Torres-Ruiz, Mon ...
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Bartmann, Kristi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Frontiers in Tox ...
- By the university
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Uppsala University