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Associations betwee...
Associations between obesity, a composite risk score for probable long COVID, and sleep problems in SARS-CoV-2 vaccinated individuals.
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- Xue, Pei (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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Merikanto, Ilona (författare)
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Delale, Eva A (författare)
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Bjelajac, Adrijana (författare)
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Yordanova, Juliana (författare)
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Chan, Rachel N Y (författare)
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Korman, Maria (författare)
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Mota-Rolim, Sérgio A (författare)
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Landtblom, Anne-Marie (författare)
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Matsui, Kentaro (författare)
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Reis, Catia (författare)
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Penzel, Thomas (författare)
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Inoue, Yuichi (författare)
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Nadorff, Michael R (författare)
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Holzinger, Brigitte (författare)
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Morin, Charles M (författare)
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Espie, Colin A (författare)
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Plazzi, Giuseppe (författare)
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De Gennaro, Luigi (författare)
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Chung, Frances (författare)
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Bjorvatn, Bjørn (författare)
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Wing, Yun Kwok (författare)
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Dauvilliers, Yves (författare)
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Partinen, Markku (författare)
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- Benedict, Christian, Docent, 1976- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: International Journal of Obesity. - 0307-0565 .- 1476-5497.
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Preliminary data suggests that obesity might hasten the decline in mRNA vaccine-induced immunity against SARS-CoV-2. However, whether this renders individuals with obesity more susceptible to long COVID symptoms post-vaccination remains uncertain. Given sleep's critical role in immunity, exploring the associations between obesity, probable long COVID symptoms, and sleep disturbances is essential.METHODS: We analyzed data from a survey of 5919 adults aged 18 to 89, all of whom received two SARS-CoV-2 mRNA vaccinations. Participants were categorized into normal weight, overweight, and obesity groups based on ethnicity-specific BMI cutoffs. The probability of long COVID was evaluated using the Post-Acute Sequelae of SARS-CoV-2 (PASC) score, as our survey did not permit confirmation of acute SARS-CoV-2 infection through methods such as antibody testing. Additionally, sleep patterns were assessed through questionnaires.RESULTS: Participants with obesity exhibited a significantly higher adjusted odds ratio (OR) of having a PASC score of 12 or higher, indicative of probable long COVID in our study, compared to those with normal weight (OR: 1.55, 95% CI: 1.05, 2.28). No significant difference was observed for overweight individuals (OR: 0.92 [95% CI: 0.63, 1.33]). Both obesity and probable long COVID were associated with increased odds of experiencing a heightened sleep burden, such as the presence of obstructive sleep apnea or insomnia (P < 0.001). However, no significant interaction between BMI and probable long COVID status was found.CONCLUSIONS: Even post-vaccination, individuals with obesity may encounter a heightened risk of experiencing prolonged COVID-19 symptoms. However, confirming our observations necessitates comprehensive studies incorporating rigorous COVID infection testing, such as antibody assays - unavailable in our anonymous survey. Additionally, it is noteworthy that the correlation between probable long COVID and sleep disturbances appears to be independent of BMI.
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Xue, Pei
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Merikanto, Ilona
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Delale, Eva A
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Bjelajac, Adrija ...
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Yordanova, Julia ...
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Chan, Rachel N Y
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visa fler...
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Korman, Maria
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Mota-Rolim, Sérg ...
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Landtblom, Anne- ...
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Matsui, Kentaro
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Reis, Catia
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Penzel, Thomas
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Inoue, Yuichi
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Nadorff, Michael ...
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Holzinger, Brigi ...
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Morin, Charles M
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Espie, Colin A
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Plazzi, Giuseppe
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De Gennaro, Luig ...
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Chung, Frances
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Bjorvatn, Bjørn
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Wing, Yun Kwok
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Dauvilliers, Yve ...
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Partinen, Markku
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Benedict, Christ ...
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visa färre...
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Uppsala universitet