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The protective role...
The protective role of commensal gut microbes and their metabolites against bacterial pathogens
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- Cheng, Liqin (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.;Cent South Univ, Changsha, Peoples R China.
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- Correia, Mario S. P. (author)
- Uppsala universitet,Institutionen för kemi - BMC,Science for Life Laboratory, SciLifeLab
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- Higdon, Shawn M. (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Garcia, Fabricio Romero (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Tsiara, Ioanna (author)
- Uppsala universitet,Institutionen för kemi - BMC,Science for Life Laboratory, SciLifeLab
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- Joffre, Enrique (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Sjoling, Asa (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.;Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden.
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- Boulund, Fredrik (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Norin, Elisabeth Lissa (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Engstrand, Lars (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.;Sci Life Lab, Stockholm, Sweden.
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- Globisch, Daniel (author)
- Uppsala universitet,Analytisk kemi,Science for Life Laboratory, SciLifeLab,Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
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- Du, Juan (author)
- Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.;Karolinska Inst, Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, S-17177 Stockholm, Sweden.
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Ctr Translat Microbiome Res CTMR, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden;Cent South Univ, Changsha, Peoples R China. Institutionen för kemi - BMC (creator_code:org_t)
- Taylor & Francis, 2024
- 2024
- English.
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In: Gut microbes. - : Taylor & Francis. - 1949-0976 .- 1949-0984. ; 16:1
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Multidrug-resistant microorganisms have become a major public health concern around the world. The gut microbiome is a gold mine for bioactive compounds that protect the human body from pathogens. We used a multi-omics approach that integrated whole-genome sequencing (WGS) of 74 commensal gut microbiome isolates with metabolome analysis to discover their metabolic interaction with Salmonella and other antibiotic-resistant pathogens. We evaluated differences in the functional potential of these selected isolates based on WGS annotation profiles. Furthermore, the top altered metabolites in co-culture supernatants of selected commensal gut microbiome isolates were identified including a series of dipeptides and examined for their ability to prevent the growth of various antibiotic-resistant bacteria. Our results provide compelling evidence that the gut microbiome produces metabolites, including the compound class of dipeptides that can potentially be applied for anti-infection medication, especially against antibiotic-resistant pathogens. Our established pipeline for the discovery and validation of bioactive metabolites from the gut microbiome as novel candidates for multidrug-resistant infections represents a new avenue for the discovery of antimicrobial lead structures.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Keyword
- Commensal bacteria
- Salmonella
- metabolite
- adenosine
- adenine
- antibiotic-resistant
- dipeptides
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cheng, Liqin
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Correia, Mario S ...
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Higdon, Shawn M.
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Garcia, Fabricio ...
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Tsiara, Ioanna
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Joffre, Enrique
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show more...
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Sjoling, Asa
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Boulund, Fredrik
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Norin, Elisabeth ...
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Engstrand, Lars
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Globisch, Daniel
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Du, Juan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
- Articles in the publication
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Gut microbes
- By the university
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Uppsala University