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Cardiac biopsies re...
Cardiac biopsies reveal differences in transcriptomics between left and right ventricle in patients with or without diagnostic signs of heart failure
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- Frisk, Christoffer (författare)
- Uppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab
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- Das, Sarbashis (författare)
- Uppsala universitet,Molekylärbiologi,Science for Life Laboratory, SciLifeLab
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- Eriksson, Maria J. (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Clin Physiol, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden.
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- Walentinsson, Anna (författare)
- AstraZeneca, Translat Sci & Expt Med, Res & Early Dev, Cardiovasc Renal & Metab,BioPharmaceut R&D, S-43183 Gothenburg, Sweden.
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- Corbascio, Matthias (författare)
- Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Dept Thorac Surg, S-17176 Stockholm, Sweden.
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- Hage, Camilla (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Heart & Vasc Theme, S-17176 Stockholm, Sweden.
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- Kumar, Chanchal (författare)
- AstraZeneca, Translat Sci & Expt Med, Res & Early Dev, Cardiovasc Renal & Metab,BioPharmaceut R&D, S-43183 Gothenburg, Sweden.;Karolinska Inst, Integrated Cardio Metab Ctr ICMC, Dept Med, S-14157 Huddinge, Sweden.
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- Ekström, Mattias (författare)
- Karolinska Inst, Danderyd Hosp, Dept Clin Sci, S-18288 Stockholm, Sweden.;Danderyd Hosp, Dept Cardiol, S-18288 Stockholm, Sweden.
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- Maret, Eva (författare)
- Karolinska Univ Hosp, Dept Clin Physiol, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden.
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- Persson, Hans (författare)
- Karolinska Institutet,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, S-18288 Stockholm, Sweden.;Danderyd Hosp, Dept Cardiol, S-18288 Stockholm, Sweden.
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- Linde, Cecilia (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, S-17177 Stockholm, Sweden.;Karolinska Univ Hosp, Heart & Vasc Theme, S-17176 Stockholm, Sweden.
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- Persson, Bengt (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,Karolinska Inst, Dept Med Biochem & Biophys, Sci Life Lab, S-17177 Stockholm, Sweden
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- Engelska.
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 14:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- New or mild heart failure (HF) is mainly caused by left ventricular dysfunction. We hypothesised that gene expression differ between the left (LV) and right ventricle (RV) and secondly by type of LV dysfunction. We compared gene expression through myocardial biopsies from LV and RV of patients undergoing elective coronary bypass surgery (CABG). Patients were categorised based on LV ejection fraction (EF), diastolic function and NT-proBNP into pEF (preserved; LVEF ≥ 45%), rEF (reduced; LVEF < 45%) or normal LV function. Principal component analysis of gene expression displayed two clusters corresponding to LV and RV. Up-regulated genes in LV included natriuretic peptides NPPA and NPPB, transcription factors/coactivators STAT4 and VGLL2, ion channel related HCN2 and LRRC38 associated with cardiac muscle contraction, cytoskeleton, and cellular component movement. Patients with pEF phenotype versus normal differed in gene expression predominantly in LV, supporting that diastolic dysfunction and structural changes reflect early LV disease in pEF. DKK2 was overexpressed in LV of HFpEF phenotype, potentially leading to lower expression levels of β-catenin, α-SMA (smooth muscle actin), and enhanced apoptosis, and could be a possible factor in the development of HFpEF. CXCL14 was down-regulated in both pEF and rEF, and may play a role to promote development of HF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Heart failure
- Ischemic heart disease
- Cardiac biopsy
- Left ventricular dysfunction
- Gene expression
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Frisk, Christoff ...
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Das, Sarbashis
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Eriksson, Maria ...
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Walentinsson, An ...
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Corbascio, Matth ...
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Hage, Camilla
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visa fler...
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Kumar, Chanchal
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Ekström, Mattias
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Maret, Eva
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Persson, Hans
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Linde, Cecilia
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Persson, Bengt
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Scientific Repor ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet