Associations Between Blood Levels of NLRP3 Inflammasome Components and Obsessive Compulsive Disorder

Tetik, MelikeDokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye. (författare)

Introduction: Even though the effect of inflammation on pathogenesis of obsessive compulsive disorder (OCD) is known, information regarding the underlying mechanisms are yet to be revealed. The NLRP3 inflammasome complex is an important component of the innate immune system that initiates and mediates inflammatory response to a variety of stimuli. This study aims to inquire into a possible association between NLRP3 inflammasome complex and OCD. Methods: This case-control study included 103 participants (51 cases with OCD and 52 healthy controls). All participants were evaluated with the Yale Brown Obsessive Compulsive Scale, Hamilton Depression Scale, and Hewitt Multidimensional Perfectionism Scale. RNA and proteins were extracted from peripheral blood mononuclear cells. Expression of NLRP3 inflammasome components were determined using quantitative real-time polymerase chain reaction (PCR) and Western blotting. Levels of Serum IL-1beta and IL-18 cytokine were determined by ELISA. Results: NEK7 and CASP1 mRNA levels were significantly higher in OCD patients, compared to controls. Pro-caspase-1 protein levels were elevated, as well. Regression analysis showed that NEK7 mRNA and procaspase-1 protein levels can differentiate OCD and healthy control groups. Conclusion: Our results provide insight into the molecular alterations that could explain the inflammation-OCD association.

Direk, NeseIstanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye. (författare)
Uzgan, Betul OnderCanakkale Onsekiz Mart Univ, Dept Biol, Canakkale, Turkiye. (författare)
Aykac, CansuDokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye. (författare)
Ekinci, BurcuDokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye. (författare)
Yaras, TutkuDokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye. (författare)
Kuruoglu, AykutDokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye. (författare)
Özel, FatihUppsala universitet,Fysiologi och miljötoxikologi(Swepub:uu)fatoz136 (författare)
Ermis, CagatayDokuz Eylul Univ, Fac Med, Dept Child & Adolescent Psychiat, Izmir, Turkiye. (författare)
Alkin, TuncDokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.;Dokuz Eylul Univ, Dept Psychiat, Fac Med, Izmir, Turkiye. (författare)
Oktay, YavuzDokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Izmir, Turkiye.;Izmir Biomed & Genome Ctr, Izmir, Turkiye.;Dokuz Eylul Univ, Fac Med, Dept Med Biol, Izmir, Turkiye. (författare)
Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye.Istanbul Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye. (creator_code:org_t)

Ingår i:Nöropsikiyatri Arşivi: Turk Noropsikiyatri Dernegi60:1, s. 28-361300-0667
Ingår i:Archives of Neuropsychiatry: Turk Noropsikiyatri Dernegi60:1, s. 28-361309-4866

Av författaren/redakt...: Tetik, Melike; Direk, Nese; Uzgan, Betul Ond ...; Aykac, Cansu; Ekinci, Burcu; Yaras, Tutku; visa fler...; Kuruoglu, Aykut; Özel, Fatih; Ermis, Cagatay; Alkin, Tunc; Oktay, Yavuz; visa färre...

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