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  • Huang, LipingGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia. (författare)

The contribution of sodium reduction and potassium increase to the blood pressure lowering observed in the Salt Substitute and Stroke Study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Springer Nature,2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-531646
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531646URI
  • https://doi.org/10.1038/s41371-024-00896-4DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The Salt Substitute and Stroke Study (SSaSS) demonstrated significant reductions in systolic blood pressure (SBP), and the risk of stroke, major cardiovascular events and total mortality with the use of potassium-enriched salt. The contribution of sodium reduction versus potassium increase to these effects is unknown. We identified four different data sources describing the association between sodium reduction, potassium supplementation and change in SBP. We then fitted a series of models to estimate the SBP reductions expected for the differences in sodium and potassium intake in SSaSS, derived from 24-h urine collections. The proportions of the SBP reduction separately attributable to sodium reduction and potassium supplementation were calculated. The observed SBP reduction in SSaSS was -3.3 mmHg with a corresponding mean 15.2 mmol reduction in 24-h sodium excretion and a mean 20.6 mmol increase in 24-h potassium excretion. Assuming 90% of dietary sodium intake and 70% of dietary potassium intake were excreted through urine, the models projected falls in SBP of between -1.67 (95% confidence interval: -4.06 to +0.73) mmHg and -5.33 (95% confidence interval: -8.58 to -2.08) mmHg. The estimated proportional contribution of sodium reduction to the SBP fall ranged between 12 and 39% for the different models fitted. Sensitivity analyses assuming different proportional urinary excretion of dietary sodium and potassium intake showed similar results. In every model, the majority of the SBP lowering effect in SSaSS was estimated to be attributable to the increase in dietary potassium rather than the fall in dietary sodium.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Li, QiangGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia. (författare)
  • Wu, Jason H. Y.George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Sch Populat Hlth, UNSW Sydney, Sydney, NSW, Australia. (författare)
  • Tian, MaoyiGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Harbin Med Univ, Sch Publ Hlth, Harbin, Peoples R China. (författare)
  • Yin, XuejunGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Chinese Acad Med Sci & Peking Union Med Coll, Sch Populat Med & Publ Hlth, Beijing, Peoples R China. (författare)
  • Yu, JieGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia. (författare)
  • Liu, YishuNanjing Med Univ, Sch Publ Hlth, Nanjing, Peoples R China. (författare)
  • Zhang, XinyiGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia. (författare)
  • Wu, YangfengPeking Univ, Clin Res Inst, Beijing, Peoples R China.;Peking Univ, Sch Publ Hlth, Beijing, Peoples R China. (författare)
  • Paige, EllieGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia. (författare)
  • Trieu, KathyGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia. (författare)
  • Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.(Swepub:uu)matma701 (författare)
  • Rodgers, AnthonyGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia. (författare)
  • Neal, BruceGeorge Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Imperial Coll London, London, England. (författare)
  • George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.George Inst Global Hlth, UNSW Sydney, Sydney, NSW, Australia.;Sch Populat Hlth, UNSW Sydney, Sydney, NSW, Australia. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Human Hypertension: Springer Nature38:4, s. 298-3060950-92401476-5527

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