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Vitamin E in relati...
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Basu, SamarUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
(författare)
Vitamin E in relation to lipid peroxidation in experimental septic shock
- Artikel/kapitelEngelska2000
Förlag, utgivningsår, omfång ...
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Elsevier BV,2000
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-53196
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-53196URI
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https://doi.org/10.1054/plef.2000.0141DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Lipid peroxidation and antioxidant balance in the body is a crucial factor in the pathophysiology of various diseases. This study investigates the circulatory alpha-tocopherol levels and its relationship with 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a non-enzymatic and, 15-keto-13,14-dihydro-PGF2alpha (15-K-DH-PGF2alpha), a cyclooxygenase catalysed oxidation product of arachidonic acid in experimental septic shock in pigs. A steady decrease in alpha-tocopherol levels in plasma was observed in both survivor and non-survivor animals. A simultaneous increase of oxidative injury indicator, plasma 8-iso-PGF2alpha was seen in both groups but with a different fashion. 8-Iso-PGF2alpha levels increased steadily in the animals that died during the experiment. An early and rapid increase of plasma 15-K-DH-PGF2alpha, an inflammatory response indicator, was also observed in all animals. There was a significant difference in the kinetics of decrement of alpha-tocopherol levels and a concomitant increase in 15-K-DH-PGF2alpha levels among the non-survivors. Thus, a successive disappearance of circulatory vitamin E in conjunction with the surge of plasma isoprostanes and prostaglandins impairs the oxidant-antioxidant balance in favour of the former and may possibly have an effect on the survivality during experimental porcine septicaemia.
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Eriksson, MatsUppsala universitet,Institutionen för kirurgiska vetenskaper,Anaesthesiology and Intensive Care
(författare)
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Uppsala universitetInstitutionen för folkhälso- och vårdvetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Prostaglandins, Leukotrienes and Essential Fatty Acids: Elsevier BV62:3, s. 195-1990952-32781532-2823
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