Sökning: id:"swepub:oai:DiVA.org:uu-53198" >
Relationships betwe...
-
Sarabi, MahziarUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
Relationships between Endothelium-Dependent Vasodilation, Serum Vitamin E and Plasma Isoprostane 8-Iso-PGF2alpha Levels in Healthy Subjects
- Artikel/kapitelEngelska1999
Förlag, utgivningsår, omfång ...
-
1999-12-24
-
S. Karger AG,1999
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-53198
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-53198URI
-
https://doi.org/10.1159/000025691DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Due to the reported associations between a low intake of vitamin E and atherosclerosis on one hand, and between endothelial dysfunction and atherosclerosis on the other hand, we investigated the relationship between endothelium-dependent vasodilation and serum levels of vitamin E (alpha- and gamma-tocopherol) as well as the lipid peroxidation markers malondialdehyde and 8-iso-PGF(2alpha) in a healthy population. Healthy subjects (31 men and 25 women), aged between 20 and 69 years, underwent measurements of forearm blood flow (FBF) at rest and during local infusion of 2 and 4 microg/min of methacholine (Mch, to evaluate endothelium-dependent vasodilation) and 5 and 10 microg/min of sodium nitroprusside (SNP, to evaluate endothelium-independent vasodilation, and during reactive hyperemia using venous occlusion plethysmography. Serum alpha-tocopherol concentration was significantly related to the index of endothelial function (r = 0.46, p < 0.01), defined as the ratio between the maximal dilatations during Mch and SNP infusions. Serum gamma-tocopherol levels were positively related to the maximal FBF during reactive hyperemia (r = 0.54, p < 0.01) in women only. Furthermore, in women only, plasma 8-iso-PGF(2alpha) levels were inversely related to the relative increases in FBF during both Mch and SNP infusions (r = -0.58 and r = -0.59, p < 0.01 for both). The results show a relationship between the levels of alpha-tocopherol and endothelial vasodilatory function, suggesting a beneficial role for this potent lipid-soluble antioxidant also in a population sample of apparently healthy subjects. Furthermore, in women, the accumulation of lipid peroxidation products such as 8-iso-PGF(2alpha) seems to be associated with an impaired vasodilation in general.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Vessby, BengtUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
(författare)
-
Basu, SamarUppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Clinical Nutrition
(författare)
-
Millgård, JonasUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
-
Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
-
Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Vascular Research: S. Karger AG36:6, s. 486-4911018-11721423-0135
Internetlänk
Hitta via bibliotek
Till lärosätets databas