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Utility of thiol/di...
Utility of thiol/disulphide homeostasis as a biomarker for acute appendicitis : a systematic review and meta-analysis
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- Krishnan, Nellai (författare)
- All India Inst Med Sci, Dept Pediat Surg, Ansari Nagar East, New Delhi 110029, Delhi, India.
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- Pakkasjarvi, Niklas (författare)
- Helsinki Univ Hosp, New Childrens Hosp, Dept Pediat Surg, Helsinki, Finland.;Univ Childrens Hosp, Dept Pediat Surg, Sect Urol, Uppsala, Sweden.
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- Kainth, Deepika (författare)
- All India Inst Med Sci, Dept Pediat, Div Neonatol, New Delhi, India.
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- Arredondo Montero, Javier (författare)
- Complejo Asistencial Univ Leon, Pediat Surg Dept, Leon, Spain.
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- Danielson, Johan, 1975- (författare)
- Univ Childrens Hosp, Dept Pediat Surg, Sect Urol, Uppsala, Sweden.
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- Verma, Pulkit (författare)
- Indian Council Med Res, Div Biomed Informat, New Delhi, India.
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- Verma, Ajay (författare)
- All India Inst Med Sci, Dept Pediat Surg, Ansari Nagar East, New Delhi 110029, Delhi, India.
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- Yadav, Devendra Kumar (författare)
- All India Inst Med Sci, Dept Pediat Surg, Ansari Nagar East, New Delhi 110029, Delhi, India.
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- Anand, Sachit (författare)
- All India Inst Med Sci, Dept Pediat Surg, Ansari Nagar East, New Delhi 110029, Delhi, India.
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All India Inst Med Sci, Dept Pediat Surg, Ansari Nagar East, New Delhi 110029, Delhi, India Helsinki Univ Hosp, New Childrens Hosp, Dept Pediat Surg, Helsinki, Finland.;Univ Childrens Hosp, Dept Pediat Surg, Sect Urol, Uppsala, Sweden. (creator_code:org_t)
- Springer, 2024
- 2024
- Engelska.
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Ingår i: Pediatric surgery international (Print). - : Springer. - 0179-0358 .- 1437-9813. ; 40:1
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to analyze the role of thiol/disulfide homeostasis (TDH) parameters as an indicator of oxidative stress in acute appendicitis (AA). PubMed, EMBASE, Web of Science, and Scopus databases were systematically searched. Studies reporting on TDH in AA (both complicated and uncomplicated cases) were included. The comparator group were healthy controls. The TDH domain was compared between the groups using anti-oxidant parameters, namely native thiol and total thiol levels, and native thiol/total thiol ratio; and oxidant parameters, namely disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio. The statistical analysis was performed using a random-effects model. The methodological quality of the studies was assessed utilizing the Newcastle-Ottawa scale. Eleven studies with a total of 926 subjects, comprising 457 patients with uncomplicated appendicitis, 147 with complicated appendicitis, and 322 healthy controls were included. Our study demonstrated significantly increased oxidative stress in AA as compared to healthy controls in all TDH parameters and significantly lower total thiol levels in complicated AA as compared to uncomplicated AA. Due to a poor methodological quality in five out of eleven studies, future prospective studies with adequate power are essential to validate these observations and refine the diagnostic approaches to AA.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Acute appendicitis
- Biomarker
- Oxidative stress
- Thiol-disulfide homeostasis
- Thiol levels
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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