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Impact of preconcep...
Impact of preconception and antenatal supplementation with myo-inositol, probiotics, and micronutrients on offspring BMI and weight gain over the first 2 years
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- Lyons-Reid, Jaz (författare)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.
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- Derraik, José G. B. (författare)
- Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Univ Auckland, Fac Med & Hlth Sci, Dept Paediat Child & Youth Hlth, Auckland, New Zealand.;Chiang Mai Univ, Res Inst Hlth Sci, Environm Occupat Hlth Sci & Noncommunicable Dis Re, Chiang Mai, Thailand.
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- Kenealy, Timothy (författare)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Univ Auckland, Dept Med, Auckland, New Zealand.;Univ Auckland, Dept Gen Practice & Primary Hlth Care, Auckland, New Zealand.
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- Albert, Benjamin B. (författare)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.
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- Nieves, J. Manuel Ramos (författare)
- Soc Prod Nestle SA, Nestle Inst Hlth Sci, Nestle Res, Lausanne, Switzerland.
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- Monnard, Cathriona R. (författare)
- Soc Prod Nestle SA, Nestle Inst Hlth Sci, Nestle Res, Lausanne, Switzerland.
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- Titcombe, Phil (författare)
- Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.
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- Nield, Heidi (författare)
- Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.
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- Barton, Sheila J. (författare)
- Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.
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- El-Heis, Sarah (författare)
- Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, England.
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- Tham, Elizabeth (författare)
- ASTAR, Singapore Inst Clin Sci, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore.;Natl Univ Singapore, Dept Obstet & Gynaecol, Singapore, Singapore.
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- Godfrey, Keith M. (författare)
- Univ Southampton, MRC Lifecourse Epidemiol Ctr, Southampton, England.;Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.;Univ Hosp Southampton NHS Fdn Trust, Southampton, England.
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- Chan, Shiao-Yng (författare)
- ASTAR, Singapore Inst Clin Sci, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore.;Natl Univ Singapore, Dept Obstet & Gynaecol, Singapore, Singapore.
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- Cutfield, Wayne S. (författare)
- Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand.;Univ Auckland, Better Start Natl Sci Challenge, Auckland, New Zealand.
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Univ Auckland, Liggins Inst, Private Bag 92019, Auckland, New Zealand Perinatal, neonatal och barnkardiologisk forskning (creator_code:org_t)
- BioMed Central (BMC), 2024
- 2024
- Engelska.
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Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 22:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this.Methods: Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo-inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis.Results: At 2 years, there was a trend towards lower mean BMI among intervention offspring (adjusted mean difference [aMD] - 0.14 SD [95% CI 0.30, 0.02], p = 0.09), and fewer had a BMI > 95th percentile (i.e. > 1.65 SD, 9.2% vs 18.0%, adjusted risk ratio [aRR] 0.51 [95% CI 0.31, 0.82], p = 0.006). Longitudinal data revealed that intervention offspring had a 24% reduced risk of experiencing rapid weight gain > 0.67 SD in the first year of life (21.9% vs 31.1%, aRR 0.76 [95% CI 0.58, 1.00], p = 0.047). The risk was likewise decreased for sustained weight gain > 1.34 SD in the first 2 years of life (7.7% vs 17.1%, aRR 0.55 [95% CI 0.34, 0.88], p = 0.014). From five weight gain trajectories identified, there were more intervention offspring in the "normal" weight gain trajectory characterised by stable weight SDS around 0 SD from birth to 2 years (38.8% vs 30.1%, RR 1.29 [95% CI 1.03, 1.62], p = 0.029).Conclusions: Supplementation with myo-inositol, probiotics, and additional micronutrients preconception and in pregnancy reduced the incidence of rapid weight gain and obesity at 2 years among offspring. Previous reports suggest these effects will likely translate to health benefits, but longer-term follow-up is needed to evaluate this.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Nutritional supplementation
- Infant weight gain
- Preconception
- Pregnancy
- Randomised trial
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Lyons-Reid, Jaz
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Derraik, José G. ...
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Kenealy, Timothy
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Albert, Benjamin ...
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Nieves, J. Manue ...
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Monnard, Cathrio ...
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visa fler...
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Titcombe, Phil
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Nield, Heidi
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Barton, Sheila J ...
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El-Heis, Sarah
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Tham, Elizabeth
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Godfrey, Keith M ...
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Chan, Shiao-Yng
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Cutfield, Wayne ...
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