SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Griffith J.)
 

Sökning: WFRF:(Griffith J.) > (2020-2024) > Targeting the ACOD1...

Targeting the ACOD1-itaconate axis stabilizes atherosclerotic plaques

Harber, Karl J. (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands.
Neele, Annette E. (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.
van Roomen, Cindy PAA. (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
visa fler...
Gijbels, Marion JJ. (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.;Univ Maastricht, CARIM Cardiovasc Res Inst Maastricht, Maastricht UMC, Dept Pathol,GROW Sch Oncol & Dev Biol, NL-6229 HX Maastricht, Netherlands.
Beckers, Linda (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
den Toom, Myrthe (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
Schomakers, Bauke, V (författare)
Univ Amsterdam, Dept Genet Metab Dis, Amsterdam UMC, NL-1105 AZ Amsterdam, Netherlands.
Heister, Daan AF. (författare)
Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands.
Willemsen, Lisa (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.
Griffith, Guillermo R. (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
de Goede, Kyra E. (författare)
Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands.;Amsterdam Gastroenterol Endocrinol Metab AGEM, Amsterdam UMC, Amsterdam, Netherlands.
van Dierendonck, Xanthe AMH. (författare)
Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands.;Amsterdam Gastroenterol Endocrinol Metab AGEM, Amsterdam UMC, Amsterdam, Netherlands.
Reiche, Myrthe E. (författare)
Uppsala universitet,Institutionen för medicinsk cellbiologi,Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands
Poli, Aurelie (författare)
Luxembourg Inst Hlth, Dept Canc Res, Neuroimmunol Grp, 6A Rue Nicolas Ernest Barble, L-1210 Luxembourg, Luxembourg.
Mogensen, Frida L-H (författare)
Luxembourg Inst Hlth, Dept Canc Res, Neuroimmunol Grp, 6A Rue Nicolas Ernest Barble, L-1210 Luxembourg, Luxembourg.
Michelucci, Alessandro (författare)
Luxembourg Inst Hlth, Dept Canc Res, Neuroimmunol Grp, 6A Rue Nicolas Ernest Barble, L-1210 Luxembourg, Luxembourg.
Verberk, Sanne GS. (författare)
Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands.
de Vries, Helga (författare)
Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands.;Amsterdam Neurosci, Amsterdam, Netherlands.
van Weeghel, Michel (författare)
Univ Amsterdam, Dept Genet Metab Dis, Amsterdam UMC, NL-1105 AZ Amsterdam, Netherlands.;Univ Amsterdam, Core Facil Metabol, Amsterdam UMC, NL-1105 AZ Amsterdam, Netherlands.
van den Bossche, Jan (författare)
Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands.
de Winther, Menno PJ. (författare)
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.
visa färre...
Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands;Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands.;Vrije Univ Amsterdam, Dept Mol Cell Biol & Immunol, Amsterdam UMC, NL-1081 HV Amsterdam, Netherlands. Univ Amsterdam, Dept Med Biochem, Amsterdam UMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Atherosclerosis & Ischem Syndromes, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Inst Infect & Immun AII, Inflammatory Dis, Amsterdam, Netherlands. (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: Redox Biology. - : Elsevier. - 2213-2317. ; 70
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Inflammatory macrophages are key drivers of atherosclerosis that can induce rupture-prone vulnerable plaques. Skewing the plaque macrophage population towards a more protective phenotype and reducing the occurrence of clinical events is thought to be a promising method of treating atherosclerotic patients. In the current study, we investigate the immunomodulatory properties of itaconate, an immunometabolite derived from the TCA cycle intermediate cis-aconitate and synthesised by the enzyme Aconitate Decarboxylase 1 (ACOD1, also known as IRG1), in the context of atherosclerosis. Ldlr-/-atherogenic mice transplanted with Acod1- /- bone marrow displayed a more stable plaque phenotype with smaller necrotic cores and showed increased recruitment of monocytes to the vessel intima. Macrophages from Acod1-/- mice contained more lipids whilst also displaying reduced induction of apoptosis. Using multi-omics approaches, we identify a metabolic shift towards purine metabolism, in addition to an altered glycolytic flux towards production of glycerol for triglyceride synthesis. Overall, our data highlight the potential of therapeutically blocking ACOD1 with the aim of stabilizing atherosclerotic plaques.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

Itaconate
IRG1
Acod1
Immunometabolism
Atherosclerosis
Macrophage

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy