Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma: Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry

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Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma : Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry

Sparber-Sauer, Monika (författare): Olga Hosp, Klinikum Landeshauptstadt Stuttgart gKAoR, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed Padiat Padiat O, Stuttgart, Germany.;Univ Med Tubingen, Tubingen, Germany.

Dietzschold, Maximilian (författare): Praxis Ebenmass, Schillerpl 5, Goppingen, Germany.

Schoenstein, Anton (författare): Heidelberg Univ, Network Aging Res, Heidelberg, Germany.

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Heinz, Amadeus (författare): Olga Hosp, Klinikum Landeshauptstadt Stuttgart gKAoR, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed Padiat Padiat O, Stuttgart, Germany.

Vokuhl, Christian (författare): Univ Hosp Bonn, Dept Pathol, Sect Pediat Pathol, Bonn, Germany.

Pajtler, Kristian W. (författare): Heidelberg Univ Hosp, Hopp Childrens Canc Ctr Heidelberg KiTZ, Heidelberg, Germany.;Heidelberg Univ, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany.;Heidelberg Univ, German Canc Consortium DKTK, Heidelberg, Germany.;Heidelberg Univ Hosp, Dept Pediat Oncol Hematol & Immunol, Heidelberg, Germany.

Harrabi, Semi (författare): Heidelberg Univ Hosp, Dept Radiat Oncol, Heidelberg, Germany.;Heidelberg Inst Radiat Oncol HIRO, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Heidelberg, Germany.;German Canc Res Ctr, Clin Cooperat Unit Radiat Oncol, Heidelberg, Germany.;Heidelberg Univ Hosp, Heidelberg Ion Beam Therapy Ctr HIT, Dept Radiat Oncol, Heidelberg, Germany.;German Canc Consortium DKTK, Heidelberg, Germany.

Lin, Yi-Lan (författare): Univ Hosp Essen, West German Proton Therapy Ctr Essen WPE, West German Canc Ctr WTZ, Dept Particle Therapy, West German, Germany.

von Kalle, Thekla (författare): Olga Hosp, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed, Inst Radiol,Klinikum Stuttgart, Stuttgart, Germany.

Hagen, Rudolf (författare): Univ Hosp Wuerzburg, Dept Otorhinolaryngol Plast Aesthet & Reconstruct, Wurzburg, Germany.

Ladenstein, Ruth (författare): St Anna Childrens Hosp, Pediat Oncol, Vienna, Austria.

Kazanowska, Bernarda (författare): Wroclaw Med Univ, Dept Pediat Hematol Oncol & BMT, Wroclaw, Poland.

Ljungman, Gustaf, 1958- (författare): Uppsala universitet,Barnonkologisk forskning - särskilt fokus på komplikationer

Klingebiel, Thomas (författare): Goethe Univ Frankfurt, Univ Hosp, Dept Children & Adolescents, Frankfurt, Germany.

Ebinger, Martin (författare): Univ Childrens Hosp, Dept Pediat Hematol & Oncol, Tubingen, Germany.

Koscielniak, Ewa (författare): Olga Hosp, Klinikum Landeshauptstadt Stuttgart gKAoR, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed Padiat Padiat O, Stuttgart, Germany.;Univ Med Tubingen, Tubingen, Germany.

Muenter, Marc (författare): Klinikum Stuttgart, Inst Radiotherapy, Stuttgart, Germany.

Timmermann, Beate (författare): Univ Hosp Essen, West German Proton Therapy Ctr Essen WPE, West German Canc Ctr WTZ, Dept Particle Therapy, West German, Germany.;German Canc Consortium DKTK, Essen, Germany.

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Olga Hosp, Klinikum Landeshauptstadt Stuttgart gKAoR, Stuttgart Canc Ctr, Zentrum Kinder Jugend & Frauenmed Padiat Padiat O, Stuttgart, Germany;Univ Med Tubingen, Tubingen, Germany. Praxis Ebenmass, Schillerpl 5, Goppingen, Germany. (creator_code:org_t)

John Wiley & Sons, 2024
2024
Engelska.
Ingår i: Pediatric Blood & Cancer. - : John Wiley & Sons. - 1545-5009 .- 1545-5017. ; 71:1

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BackgroundParameningeal location of rhabdomyosarcoma (PM RMS) is known to be an unfavorable prognostic factor. Scarce data are available on radiotherapy (RT) concepts with regard to outcome.MethodsTreatment and outcome of 395 children with PM RMS registered within two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry (1995-2021) were evaluated.ResultsPatients were IRS group II (n = 15) and III (n = 380) and received systemic treatment according to the enrolled protocols: I2VA (n = 172), VAIA/CEVAIE (n = 223). Delayed resection was performed in 88/395 (22%) patients, and RT was additionally given in 79/88 (90%) resected patients. RT was the predominant local treatment in 355/395 (90%) patients: hyperfractionated accelerated photon (HART; n = 77), conventionally fractionated photon (n = 91) or proton beam (n = 126), brachytherapy (n = 4), heavy ions (n = 1), not available (n = 56). In the subgroup of RT as only local treatment (n = 278), no intracranial tumor extension and complete remission at end of treatment were significant positive prognostic factors. No significant difference on tumor outcome was seen between different radiotherapy concepts. Long-term toxicity with mostly endocrinological and visual deficiencies was reported in 161/279 (58%) surviving patients with a lower trend after proton beam RT (48%) when compared to HART or conventionally fractionated photon RT (71% and 72%, respectively). Ten-year event-free and overall survival in the overall group were 62% (+/- 5, 95% confidence interval [CI]) and 67% (+/- 5, 95% CI); in the RT-only group 67% (+/- 6, 95% CI) and 71% (+/- 6, 95% CI), respectively.ConclusionCWS data confirm the recent RT concept in PM RMS. Long-term sequelae as endocrinological and visual deficiencies need to be addressed.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Hematologi

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Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma : Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry

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