Sökning: WFRF:(Lewén Anders 1965 ) >
Machine learning ba...
Machine learning based prediction of imminent ICP insults during neurocritical care of traumatic brain injury
-
- Galos, Peter (författare)
- Uppsala universitet,Neurokirurgi
-
- Hult, Ludvig (författare)
- Uppsala universitet,Avdelningen för systemteknik,Artificiell intelligens
-
- Zachariah, Dave (författare)
- Uppsala universitet,Avdelningen för systemteknik,Reglerteknik,Artificiell intelligens
-
visa fler...
-
- Lewén, Anders, 1965- (författare)
- Uppsala universitet,Neurokirurgi
-
- Hånell, Anders (författare)
- Uppsala universitet,Neurokirurgi
-
- Howells, Timothy (författare)
- Uppsala universitet,Neurokirurgi
-
- Schön, Thomas, Professor, 1977- (författare)
- Uppsala universitet,Avdelningen för systemteknik,Reglerteknik,Artificiell intelligens
-
- Enblad, Per (författare)
- Uppsala universitet,Neurokirurgi
-
visa färre...
-
(creator_code:org_t)
- Engelska.
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background/ObjectiveIncreased intracranial pressure (ICP) is a feared secondary brain insult in neurointensive care (NIC) of traumatic brain injury (TBI). A system that predicts ICP insults before they emerge may facilitate early optimization of the physiology, which in turn may lead to that the predicted ICP insult will never occur. The aim of this study was to evaluate the performance of different AI models in predicting risk of ICP insults. MethodsThe models were trained to predict risk of ICP insults starting within 30 minutes, using the Uppsala High Frequency TBI (UHF-TBI) dataset. A restricted dataset consisting of monitoring data only was used, and an unrestricted dataset using monitoring data as well as clinical data, demographic data and radiological evaluations. Four different model classes were compared: Gaussian Process Regression (GP), Logistic Regression (LR), Random Forest classifier (RF) and Extreme Gradient Boosted Decision Trees (XGBoost).ResultsSix hundred and two TBI patients were included (total monitoring 138 411 hours). On the task of predicting upcoming ICP insults, the GP model performed similar on the UHF-TBI dataset (sensitivity 93.2% and specificity 93.9%), as in earlier smaller studies. Using a more flexible model (XGBoost) resulted in slightly better performance (sensitivity 93.8% and specificity 94.6%). Adding more clinical variables and features further improved the performance of the models slightly (XGBoost: sensitivity 94.1% and specificity of 94.6%). Using AUROC as performance measure, the XGBoost models also performed slightly better than the other models. ConclusionsAI models have potential to become valuable tools for prediction of ICP insults in advance during NIC. The fact that common off-the-shelf models, such as XGBoost, performed well in predicting ICP insults opens for new possibilities, which can lead to faster advances in the field and faster clinical implementations.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik -- Signalbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering -- Signal Processing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)
- Av författaren/redakt...
-
Galos, Peter
-
Hult, Ludvig
-
Zachariah, Dave
-
Lewén, Anders, 1 ...
-
Hånell, Anders
-
Howells, Timothy
-
visa fler...
-
Schön, Thomas, P ...
-
Enblad, Per
-
visa färre...
- Om ämnet
-
- TEKNIK OCH TEKNOLOGIER
-
TEKNIK OCH TEKNO ...
-
och Elektroteknik oc ...
-
och Signalbehandling
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Av lärosätet
-
Uppsala universitet