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Subsets of T-cells ...
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Pauksen, KarlisUppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
(författare)
Subsets of T-cells and in vitro cytokine production after measles and varicellae-zoster virus antigen stimulation in allogeneic BMT patients
- Artikel/kapitelEngelska1999
Förlag, utgivningsår, omfång ...
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Informa UK Limited,1999
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-54535
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-54535URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1943449URI
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https://doi.org/10.1080/00365549950161871DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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This study was performed to analyse differences in T-cell proliferation induced by a latent virus, varicellae-zoster virus (VZV) and a non-latent virus, measles virus, in patients after allogeneic bone marrow transplantation (BMT). The lymphoproliferative response to measles antigen, VZV-antigen (VZV-ag), and phytohemagglutinin (PHA) was measured by 3H-thymidine incorporation, and interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) analyses in supernatants after in vitro stimulation of peripheral blood mononuclear cells (PBMC) from 22 patients and 18 healthy controls. The cytokine levels were correlated with T-cell subsets by FACS analyses. At the antigen concentrations used, VZV-ag induced higher levels of IFN-gamma (p < 0.05) than did the measles antigen, whereas the levels of IL-10 were similar. Patients without a cell mediated immune (CMI) response to VZV-ag or measles antigen had lower CD4+ T-cell counts than did controls (p < 0.01 in both cases) and lower IFN-gamma production after non-specific PHA stimulation (p <0.01). The IFN-gamma and IL-10 levels after measles antigen stimulation correlated with the number of CD4+ T-cells (p < 0.01 and p < 0.05, respectively), and after VZV-ag mainly to the number of CD8+ T-cells (p < 0.01 and p < 0.05, respectively). These results suggest that there is a difference in the types of T-cells that respond to VZV-ag and measles antigen stimulation, respectively. The impaired CMI response to viral antigens seen in many patients may be explained both by a low number of CD4+ T-cells and by a cell dysfunction.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sjölin, JanUppsala universitet,Institutionen för medicinska vetenskaper,Friman, infektion
(författare)
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Linde, Annika
(författare)
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Andersson, Birger
(författare)
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Lenkei, Rodica
(författare)
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Öberg, GunnarUppsala universitet,Institutionen för medicinska vetenskaper,Hematologigruppen, B Simonsson
(författare)
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Ljungman, PerKarolinska Institutet
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian Journal of Infectious Diseases: Informa UK Limited31:1, s. 43-490036-55481651-1980
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