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Hyperparathyroidism...
Hyperparathyroidism of multiple endocrine neoplasia type 1 : candidate gene and parathyroid calcium sensing protein expression
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- Carling, Tobias (author)
- Uppsala universitet,Medicin,Institutionen för kirurgiska vetenskaper
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- Rastad, Jonas (author)
- Uppsala universitet,Endokrinkirurgi,Medicin
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- Ridefelt, Peter (author)
- Uppsala universitet,Medicin,Institutionen för kirurgiska vetenskaper
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- Gobl, Anders (author)
- Uppsala universitet,Medicin,Institutionen för kirurgiska vetenskaper
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- Hellman, Per (author)
- Uppsala universitet,Medicin,Endokrinkirurgi
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- Öberg, Kjell (author)
- Uppsala universitet,Medicin,Institutionen för kirurgiska vetenskaper
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- Rask, Lars (author)
- Karolinska Institutet,Uppsala universitet,Medicin,Institutionen för kirurgiska vetenskaper
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- Larsson, Catharina (author)
- Uppsala universitet,Medicin,Institutionen för kirurgiska vetenskaper
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- Juhlin, Claes (author)
- Uppsala universitet,Endokrinkirurgi,Medicin
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- Åkerström, Göran (author)
- Uppsala universitet,Endokrinkirurgi,Medicin
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- Skogseid, Britt (author)
- Uppsala universitet,Endokrin tumörbiologi
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(creator_code:org_t)
- 1995
- 1995
- English.
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In: Surgery. - 0039-6060 .- 1532-7361. ; 118:6, s. 924-931
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND:Hyperparathyroidism affects most patients with multiple endocrine neoplasia type 1 (MEN 1). This study investigates expression of the candidate MEN1 gene phospholipase C beta 3 (PLC beta 3) and expression and function of a putative calcium sensing protein (CAS) in hyperparathyroidism of MEN 1.METHODS:In 31 parathyroid glands from 17 patients with MEN 1, CAS distribution was studied immunohistochemically and parallel sections were explored for PLC beta 3 mRNA expression by in situ hybridization. Enzymatically dispersed parathyroid cells were analyzed for cytoplasmic calcium concentrations [Ca2+]i and parathyroid hormone (PTH) release.RESULTS:All glands exhibited a heterogeneously reduced CAS immunoreactivity, especially meager in nodularly assembled parathyroid cells. Calcium regulated [Ca2+]i and PTH release tended to be more deranged in the glands possessing the lowest immunostaining. Parathyroid PLC beta 3 invariably was homogeneously expressed, and this included even MEN 1 patients with reduced PLC beta 3 expression in endocrine pancreatic tumors.CONCLUSIONS:The findings support variable calcium insensitivity of [Ca2+]i and PTH release in hyperparathyroidism of MEN 1, apparently coupled to heterogeneously reduced CAS expression. For clarification of the role of PLC beta 3 in MEN 1 parathyroid tumorigenesis further study of this protein is required.
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- ref (subject category)
- art (subject category)
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Surgery
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To the university's database
- By the author/editor
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Carling, Tobias
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Rastad, Jonas
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Ridefelt, Peter
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Gobl, Anders
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Hellman, Per
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Öberg, Kjell
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show more...
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Rask, Lars
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Larsson, Cathari ...
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Juhlin, Claes
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Åkerström, Göran
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Skogseid, Britt
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show less...
- Articles in the publication
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Surgery
- By the university
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Uppsala University
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Karolinska Institutet