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Biosynthesis and fu...
Biosynthesis and function of all-trans- and 9-cis retinoic acid in parathyroid cells
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- Liu, Wei (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
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- Hellman, Per (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
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- Li, Qing (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Yu, Wen-Ru (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Juhlin, Claes (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
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- Nordlinder, Hans (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Rollman, Ola (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatology and Venereology
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- Åkerström, Göran (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Endocrine Surgery
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- Törmä, Hans (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatology and Venereology
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- Melhus, Håkan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Osteoporos
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(creator_code:org_t)
- Elsevier BV, 1996
- 1996
- English.
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In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 229:3, s. 922-929
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We demonstrate that cultured human and bovine parathyroid cells incubated with all-trans-[11,12-3H]-retinol convert this tracer into all-trans- and 9-cis-retinoic acid. By using RT-PCR, cellular retinol-binding protein type I (CRBP I), cellular retinoic acid binding protein I and II (CRABP I and II), retinoic acid receptors (RARs) alpha, beta and gamma, and 9-cis-retinoic acid receptor (RXR) alpha transcripts were detected in human parathyroid cDNA. CRBP I and CRABP I expression was confirmed by immunohistochemistry. Both 9-cis- and all-trans-RA were found to suppress parathyroid hormone (PTH) secretion from dispersed human adenomatous parathyroid cells, which was augmented by combined treatment with 1mM RA and 100 nM 1,25 (OH)2D3. The present data establish parathyroid gland as a target for retinoids and as a site of synthesis of the hormonal forms of vitamin A (retinol), all-trans- and 9-cis-retinoic acid.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Liu, Wei
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Hellman, Per
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Li, Qing
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Yu, Wen-Ru
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Juhlin, Claes
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Nordlinder, Hans
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show more...
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Rollman, Ola
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Åkerström, Göran
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Törmä, Hans
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Melhus, Håkan
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show less...
- Articles in the publication
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Biochemical and ...
- By the university
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Uppsala University