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Assessment of eryth...
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Beshara, SoheirUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
Assessment of erythropoiesis following renal transplantation
- Artikel/kapitelEngelska1997
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LIBRIS-ID:oai:DiVA.org:uu-55254
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-55254URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ten patients, who received cadaveric kidneys, were followed for 24 wk with serial measurements of serum erythropoietin (S-Epo), transferrin receptor (S-TfR) and iron variables. The mean pretransplant creatinine clearance was 8.2 (range 0-22) ml/min and the mean haemoglobin (Hb) level was 99 +/- 18.6 (range 66-124) g/l. Nine patients demonstrated a gradual increase in S-Epo levels, which reached a peak, and was accompanied by a parallel increase in S-TfR levels with a median lag period of 3 wk between both peaks. Hb correction followed the S-TfR peak after a second lag period (median 7 wk). Elevated S-Epo and S-TfR did not result in correction of anaemia in 1 patient due to impaired graft function. Within 4 months, S-Epo levels reached the normal range while TfR levels were higher than normal. Follow-up of iron status demonstrated the development of iron deficiency in 5 patients, which was corrected spontaneously. Improvement in erythropoiesis after renal transplantation seems to occur by means of expansion of the erythroid marrow, as detected by increasing S-TfR levels, subsequent to a S-Epo peak. This expansion precedes Hb normalization. A nonuraemic environment is probably a prerequisite for the correction of anaemia but not for the increase in S-Epo or S-TfR levels. Iron deficiency may occur after transplantation due to an increase in iron utilization.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Birgegård, GunnarUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
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Goch, J.Uppsala universitet,Institutionen för medicinska vetenskaper
(författare)
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Wahlberg, JanUppsala universitet,Institutionen för kirurgiska vetenskaper,Transplantation Surgery
(författare)
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Wikström, BjörnUppsala universitet,Institutionen för medicinska vetenskaper
(författare)
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Danielson, Bo G.Uppsala universitet,Institutionen för medicinska vetenskaper
(författare)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Haematology58:3, s. 167-1730902-44411600-0609
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