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  • Altraja, Alan (author)

Expression of laminins in the airways in various types of asthmatic patients: A morphometric study

  • Article/chapterEnglish1996

Publisher, publication year, extent ...

  • 1996
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-55406
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-55406URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Laminins (Ln) are crucial in airway morphogenesis. Because they are able to interact with inflammatory cells, they are likely to participate in inflammation accompanied by airway structural remodeling in asthma. Taking biopsies and using immunohistochemistry and quantitative image analysis, we characterized the distribution of Ln chains alpha 1, alpha 2, and beta 2 in the bronchial mucosa of patients with seasonal (n = 17), early occupational (n = 8), and chronic asthma (n = 16) for comparison with that of normal controls (n = 8). In all asthmatic patients, both Ln chains alpha 1 and beta 2 were confined to the superficial margin of the basement membrane (BM), blood vessels, and smooth muscle. The thickness of Ln beta 2 expression in BM was significantly greater in patients with chronic (1.9 +/- 0.1 microns; P < 0.001) and occupational asthma (1.7 +/- 0.1 microns; P < 0.05) than in controls (0.4 +/- 0.3 microns). Only in patients with occupational asthma was the thickness of the Ln alpha 1 layer (2.3 +/- 0.2 microns; mean +/- SEM) significantly different from that in controls (1.4 +/- 0.5 microns; P < 0.05). There was no immunoreactivity for the Ln alpha 2 chain in controls or patients with mild asthma, but in clinically severe chronic asthma we found a discontinuous staining along the epithelial margin of the BM. Since Ln chains alpha 2 and beta 2 appear to function only during morphogenesis, increased expression of these Ln chains in adult asthma patients suggests accelerated tissue turnover in the airways, possibly as a result of airway inflammation in asthma.

Subject headings and genre

  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Laitinen, Annika (author)
  • Virtanen, Ismo (author)
  • Kämpe, MaryUppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Simonsson, Bo G.Uppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Karlsson, Sven-Erik (author)
  • Håkansson, LenaUppsala universitet,Institutionen för medicinska vetenskaper (author)
  • Venge, PerUppsala universitet,Institutionen för medicinska vetenskaper,Clinical Chemistry(Swepub:uu)pervenge (author)
  • Sillastu, Heinart (author)
  • Laitinen, Lauri A. (author)
  • Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:American Journal of Respiratory Cell and Molecular Biology15:4, s. 482-4881044-15491535-4989

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