Cognitive decline in patients with symptomtic HIV-1 infection: No decline in asymptomatic infection

Cognitive decline in patients with symptomtic HIV-1 infection : No decline in asymptomatic infection

Thirty-six HIV-1-infected predominantly well-functioning subjects were followed up for one year by repeated neuropsychological, clinical neurological, neuroradiological, and immunological examinations. Changes in cognitive performance related to the severity of HIV-1 infection as well as to neuroradiological or immunological changes were studied. A decline in cognitive speed and flexibility was found in symptomatic subjects (ARC, AIDS). The impairment was especially pronounced in patients with progression of brain atrophy. These findings suggest a brain pathology underlying the cognitive decline in ambulatory outpatients with symptomatic HIV-1 infection. A practice effect was found in asymptomatic subjects (ASX, LAS) and in those with unchanged CT/MRI scans. No systematic relationship was found between cognitive change and immunological change.

Elovaara, I. (author)
Raininko, RailiUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,RAD (author)
Vilkki, J. (author)
Lähdevirta, J. (author)
Iivanainen, M. (author)
Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)

By the author/editor: Poutiainen, E.; Elovaara, I.; Raininko, Raili; Vilkki, J.; Lähdevirta, J.; Iivanainen, M.

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