Genetic risk factors and ischemic cerebrovascular disease: role of common variation of the genes encoding apolipoproteins and angiotensin-converting enzyme

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: (WAKA:art) srt2:(1980-1999) > Genetic risk factor...

Details
MARC

Aalto-Setälä, Katriina (author)

Genetic risk factors and ischemic cerebrovascular disease : role of common variation of the genes encoding apolipoproteins and angiotensin-converting enzyme

Article/chapterEnglish1998

Publisher, publication year, extent ...

1998
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-57603
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-57603URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

DNA polymorphisms in genes encoding apolipoproteins (apo) A-I, C-III, B and E and angiotensin-converting enzyme (ACE) have been proposed to be associated with the risk of coronary artery disease (CAD). We studied whether the same genetic markers would also be associated with the occurrence and extent of atherosclerosis in cervical arteries. DNA samples from 234 survivors of stroke or a transient ischaemic attack aged 60 years or less were examined. The presence of atherosclerosis was assessed using aortic arch angiograms. The SstI polymorphism of apoA-I/C-III gene locus, the XbaI polymorphism of apoB gene, common apoE phenotypes and the insertion/deletion polymorphism of the ACE gene were analysed. The allele frequencies of the apoA-I/C-III, apoB, apoE or ACE gene did not differ between the groups with (n = 148) or without (n = 85) cervical atherosclerosis. However, when patients with at least one apoE4 allele and one X2 allele of apoB were combined and compared with those without either of them (E2E3 or E3E3 and X1X1), a significant association with the presence of cervical atherosclerosis was found (P = 0.03). The patients having the E2E3 phenotype had a significantly elevated serum triglyceride level compared with those with the E3E3 phenotype (P = 0.03). Serum high-density lipoprotein (HDL) cholesterol was lower in the patients with the E2E3 phenotype than in those with the E3E3 and E3E4 (P = 0.01 and P = 0.06, respectively). The apoB or ACE genotypes were not significantly associated with serum lipid or lipoprotein levels. There was no association between the ACE gene polymorphism and the occurrence of hypertension. In conclusion, the interaction of common apoB and apoE alleles may increase the risk of atherosclerosis in cervical arteries.

Subject headings and genre

MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Palomäki, Heikki (author)
Miettinen, Helena (author)
Vuorio, Alpo (author)
Kuusi, Timo (author)
Raininko, RailiUppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi,RAD (author)
Salonen, Oili (author)
Kaste, Markku (author)
Kontula, Kimmo (author)
Uppsala universitetInstitutionen för onkologi, radiologi och klinisk immunologi (creator_code:org_t)

Related titles

In:Annals of Medicine30:2, s. 224-330785-38901365-2060

Internet link

https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-57603

Find in a library

Annals of Medicine (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Aalto-Setälä, Ka ...; Palomäki, Heikki; Miettinen, Helen ...; Vuorio, Alpo; Kuusi, Timo; Raininko, Raili; show more...; Salonen, Oili; Kaste, Markku; Kontula, Kimmo; show less...

Articles in the publication: Annals of Medici ...

By the university: Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se