Food Antigen Sensitivity in Coeliac Disease Assessed by the Mucosal Patch Technique

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Hällgren Roger) > Food Antigen Sensit...

Kristjánsson, Guðjón,1962-Uppsala universitet,Institutionen för medicinska vetenskaper (författare)

Food Antigen Sensitivity in Coeliac Disease Assessed by the Mucosal Patch Technique

BokEngelska2005

Förlag, utgivningsår, omfång ...

Uppsala :Acta Universitatis Upsaliensis,2005
69 s.
electronicrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-6020
ISBN:9155463746
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6020URI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:vet swepub-contenttype
Ämneskategori:dok swepub-publicationtype

Serie

Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,1651-6206 ;80

Anmärkningar

A diagnosis of coeliac disease (CD) in adults relies on the presence of a structurally abnormal intestinal mucosa, followed by a clear clinical remission on a gluten-free diet. There is a clear need for a rapid, simple, safe and sensitive method to determine the type and intensity of inflammation in the gut mucosa in clinical practice. The overall aims of our studies were to develop and evaluate a new technique, “the mucosal patch technique”, to characterize rectal local inflammatory process after rectal food challenge in patients with CD. In study 1 we evaluated the potential of the new technique. The technique was well tolerated and easily applied. Pronounced neutrophil and eosinophil involvement in ulcerative colitis (UC) was demonstrated. With the high sensitivity of the technique, low-degree mucosal neutrophil activation could also be quantified in patients with collagen colitis,UC in clinical remission and in patients with irritable bowel syndrome. In study 2 and 3 the aim was to elucidate the dynamics of the rectal inflammatory response and nitric oxide (NO) production after rectal gluten challenge. We found a pronounced neutrophil activation in coeliac patients after rectal gluten challenge. This activation was apparent 4 hours after challenge and remains for at least 48 hours. A more modest eosinophil activation started 1-2 hours later and remained at least for 48 hours. The biphasic pattern of neutrophil and eosinonphil activation after challenge suggests a biphasic inflammatory reaction. The activation of neutrophils and eosinophils precedes a pronounced enhancement of mucosal NO production. Some of our coeliac patients displayed signs of an inflammatory reaction after rectal corn gluten challenge. In study 4 the aim was to investigate the local inflammatory reaction to gluten and cow’s milk protein in CD patients in remission. The findings indicate that not only gluten sensitivity but also cow’s milk (CM) protein sensitivity is common in CD. The data support the hypothesis that CM sensitivity may contribute to persistent symptoms in coeliac patients on gluten-free diet.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
Medicine
Coeliac disease
Diagnostic instrument
food hypersensitivity
gut pathophysiologi
inflammation
nitric oxide
rectal instillation
gluten
corn
milk hypersensitivity
inflammatory bowel disease
irritable bowel syndrome
Medicin
Dermatology and venerology,clinical genetics, internal medicine
Dermatologi och venerologi, klinisk genetik, invärtesmedicin

Biuppslag (personer, institutioner, konferenser, titlar ...)

Hällgren, Roger (preses)
Venge, Per (preses)
Troncone, Riccardo,ProfessonrDepartment of Pediatrics & European Laboratory for the investigation of food-induced diseases, University Federico II, Napoli (opponent)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Internetlänk

Hitta via bibliotek

Food Antigen Sensitivity in Coeliac Disease Assessed by the Mucosal Patch Techni... (Sök publikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Kristjánsson, Gu ...; Hällgren, Roger; Venge, Per; Troncone, Riccar ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Dermatologi och ...

Delar i serien: Digital Comprehe ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se